Pentraxin-3 in hemodialysis patients : relationship to comorbidities
المؤلفون المشاركون
al-Sibai, Azizah Ahmad
Abd al-Al, Halah
al-Sayyid, Engy Yusri
al-Hadidi, Iman Salih
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 27، العدد 4 (31 أغسطس/آب 2016)، ص ص. 701-709، 9ص.
الناشر
تاريخ النشر
2016-08-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Hemodialysis (HD), despite being the most common treatment modality for endstage renal disease (ESRD), still carries a mortality rate higher than 20–50%/year resulting from various comorbidities.
The aim of this study was to measure the plasma level of pentraxin-3 (PTX-3) in patients on maintenance HD and to assess its relationships to comorbidities such as malnutrition and associated comorbid diseases.
This case–control study included 50 HD patients, 30 ESRD patients, and 30 healthy controls.
HD patients were classified into different subgroups according to the Davies comorbidity index and malnutrition score.
Plasma PTX-3 was analyzed by a sandwich ELISA technique.
Plasma level of PTX-3 reached its highest levels in HD patients followed by ESRD patients as compared to healthy controls.
Moreover, within the different subgroups, the highest levels and the highest odd ratio of PTX-3 were detected in the subgroups having the highest Davies comorbidity index or the highest malnutrition score as compared to the other subgroups.
At a cutoff of 0.6 ng/mL, PTX-3 was able to discriminate HD patients with low Davies comorbidity index from those with both medium and high Davies comorbidity index with a diagnostic sensitivity of 92.5% and a diagnostic specificity of 70.0%.
Meanwhile, the best cutoff of plasma PTX-3 for discriminating patients with mild malnutrition from severe and moderate malnutrition was 0.6 ng/mL with a diagnostic sensitivity of 90.9% and a diagnostic specificity of 41.2%.
In conclusion, PTX-3 appears to be a clinically useful marker for the early identification of patients with renal failure on maintenance HD who are at substantially increased risk of morbidity.
These patients may require care and aggressive follow-up in more specialized units and an early referral to a renal transplant center
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sibai, Azizah Ahmad& al-Hadidi, Iman Salih& Abd al-Al, Halah& al-Sayyid, Engy Yusri. 2016. Pentraxin-3 in hemodialysis patients : relationship to comorbidities. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 4, pp.701-709.
https://search.emarefa.net/detail/BIM-693065
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sibai, Azizah Ahmad…[et al.]. Pentraxin-3 in hemodialysis patients : relationship to comorbidities. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 4 (Jul. / Aug. 2016), pp.701-709.
https://search.emarefa.net/detail/BIM-693065
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sibai, Azizah Ahmad& al-Hadidi, Iman Salih& Abd al-Al, Halah& al-Sayyid, Engy Yusri. Pentraxin-3 in hemodialysis patients : relationship to comorbidities. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 4, pp.701-709.
https://search.emarefa.net/detail/BIM-693065
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 708-709
رقم السجل
BIM-693065
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر