Level and onset of cmv-pp65 antigenemia as determinants of risk for cmv-related complications in stem cell transplant recipients
المؤلفون المشاركون
Fahmi, Umar Ahmad
Kamil, Husam Muhammad
al-Attar, Inas
al-Mahallawy, Haydar Ahmad
al-Sharqawi, Nahla M.
Kamil, Azzah
Salah, Fatimah
al-Hadda, Ala
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 13، العدد 4 (31 ديسمبر/كانون الأول 2001)، ص ص. 259-266، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2001-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study was carried out to investigate if quantification of CMV antigen can be used to risk adapt the prophylaxis for CMV infection in stem cell transplant recipients in order to reduce the cost and the number of patients who are exposed to ganciclovir.
Assay for CMV early antigen pp65 on circulating leukocytes was used to monitor early CMV infection in 54 consecutive patients undergoing peripheral blood stem cell transplantation (PBSCT).
A total of 201 samples were examined for CMV antigen in peripheral blood leukocytes by the slide method and 40 samples were additionally investigated by flow cytometry.
Of 54 patients examined, twenty five patients (46 %) were positive for CMV pp65 antigen.
Eleven of these patients developed CMV disease following PBSCT.
Patients who suffered from CMV disease showed statistically significantly higher OT levels (p = 0.003), higher frequency of complications (p = 0.008) and unfavorable outcome (p = 0.002).
Patients who were positive for CMV antigen had a 4.5 times higher risk to develop GVHD.
In multivariate analysis, we found that CMV pp65 antigen positivity was the only factor which was independently related to GVHD.
On comparing the detection of antigenemia by the slide method to that by flow cytometry, the slide method was statistically significantly more sensitive in diagnosing patients who manifested with CMV-related disease (p = 0.01).
Thus, antigenemia can be used to assign PBSCT recipients at risk for CMV disease and risk adapted prophylaxis for CMV can be carried out according to the level of CMV positive leukocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Mahallawy, Haydar Ahmad& al-Sharqawi, Nahla M.& al-Hadda, Ala& al-Attar, Inas& Fahmi, Umar Ahmad& Kamil, Azzah…[et al.]. 2001. Level and onset of cmv-pp65 antigenemia as determinants of risk for cmv-related complications in stem cell transplant recipients. Journal of the Egyptian National Cancer Institute،Vol. 13, no. 4, pp.259-266.
https://search.emarefa.net/detail/BIM-69363
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Mahallawy, Haydar Ahmad…[et al.]. Level and onset of cmv-pp65 antigenemia as determinants of risk for cmv-related complications in stem cell transplant recipients. Journal of the Egyptian National Cancer Institute Vol. 13, no. 4 (Dec. 2001), pp.259-266.
https://search.emarefa.net/detail/BIM-69363
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Mahallawy, Haydar Ahmad& al-Sharqawi, Nahla M.& al-Hadda, Ala& al-Attar, Inas& Fahmi, Umar Ahmad& Kamil, Azzah…[et al.]. Level and onset of cmv-pp65 antigenemia as determinants of risk for cmv-related complications in stem cell transplant recipients. Journal of the Egyptian National Cancer Institute. 2001. Vol. 13, no. 4, pp.259-266.
https://search.emarefa.net/detail/BIM-69363
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 265-266
رقم السجل
BIM-69363
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر