Bone marrow angiogenesis in patients with hematological malignancies : role of VEGF
المؤلفون المشاركون
al-Sayyid, Amr
Abd al-Rahman, Muhammad
al-Ghandur, Ashraf H.
Deghady, Akram A.
al-Sorady, Manal
al-Burdini, Majdi
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 12، العدد 2 (30 يونيو/حزيران 2000)، ص ص. 131-136، 6ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2000-06-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
The formation of new capillaries from pre-existing blood vessels is known as angiogenesis.
This process is enhanced by several cytokines including basic fibroblastic growth factor (bFGF), IL-8, vascular endothelial growth factor (VEGF) and others.
VEGF appears to be the most relevant cytokine in this respect, since its expression is closely correlated with vessel density in several human tumors and inhibition of VEGF by specific antibodies suppresses tumor growth.
The aim of our work was to study BM angiogenesis in a variety of hematopoietic neoplasms and to investigate any possible role for VEGF in the growth of such neoplasms.
A total of 80 patients with various hematological neoplasms were evaluated for BM angiogenesis.
They were divided into 4 groups including 20 patients with non-Hodgkin's lymphoma and 20 patients with Hodgkin's disease, both with bone marrow infiltration, 20 patients with multiple myeloma and 20 patients with acute leukemia.
Sera from patients and controls were collected for estimation of VEGF.
Our results showed that both microvessel density in BM biopsies and serum VEGF levels in patients with hematological malignancies significantly exceeded those of the controls.
Also, there was a significant positive correlation between the vessel count and VEGF levels in patients with both MM and NHL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sorady, Manal& Abd al-Rahman, Muhammad& al-Burdini, Majdi& al-Ghandur, Ashraf H.& al-Sayyid, Amr& Deghady, Akram A.. 2000. Bone marrow angiogenesis in patients with hematological malignancies : role of VEGF. Journal of the Egyptian National Cancer Institute،Vol. 12, no. 2, pp.131-136.
https://search.emarefa.net/detail/BIM-69434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sorady, Manal…[et al.]. Bone marrow angiogenesis in patients with hematological malignancies : role of VEGF. Journal of the Egyptian National Cancer Institute Vol. 12, no. 2 (Jun. 2000), pp.131-136.
https://search.emarefa.net/detail/BIM-69434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sorady, Manal& Abd al-Rahman, Muhammad& al-Burdini, Majdi& al-Ghandur, Ashraf H.& al-Sayyid, Amr& Deghady, Akram A.. Bone marrow angiogenesis in patients with hematological malignancies : role of VEGF. Journal of the Egyptian National Cancer Institute. 2000. Vol. 12, no. 2, pp.131-136.
https://search.emarefa.net/detail/BIM-69434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 135-136
رقم السجل
BIM-69434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر