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Frequent allelic losses at the short arm of chromosome 3p in invasive ductal carcinoma of breast in Egypt
المؤلف
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 12، العدد 2 (30 يونيو/حزيران 2000)، ص ص. 145-150، 6ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2000-06-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Breast cancer is one of the most common cancers affecting women in western countries as well as in Egypt.
Deletion on the short arm of chromosome 3 (3p) has been detected in breast cancer using cytogenetic and loss of heterozygosity (LOH) studies which suggested the presence of tumor suppressor gene loci on that chromosomal arm.
In this report 45 cases of invasive ductal carcinoma of breast were studied for LOH using 10 highly polymorphic microsatellite markers distributed over the short arm of chromosome 3 (3p).
LOH was observed in 87 % of the cases examined.
In this study, three common regions on 3p chromosome showed LOH.
The highest LOH was detected at the 3p14-13 region which showed 42.75 % of allelic losses.
The second region was at 3p14.2-14.1 where 21 % of allelic losses were observed.
This region contains the recently identified Fragile Histidine Triad (FHIT) tumor suppressor gene.
The last region that showed LOH was at 3p21.1-14.3 region which exhibited 21 % losses.
No significant correlation was observed between LOH and different clinico-pathological parameters.
These results suggest that 3 or more tumor suppressor gene regions on the short arm of chromosome 3 including the FHIT gene may play an important role in breast cancer tumorigenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Wahhab, Abd al-Hadi A.. 2000. Frequent allelic losses at the short arm of chromosome 3p in invasive ductal carcinoma of breast in Egypt. Journal of the Egyptian National Cancer Institute،Vol. 12, no. 2, pp.145-150.
https://search.emarefa.net/detail/BIM-69443
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Wahhab, Abd al-Hadi A.. Frequent allelic losses at the short arm of chromosome 3p in invasive ductal carcinoma of breast in Egypt. Journal of the Egyptian National Cancer Institute Vol. 12, no. 2 (Jun. 2000), pp.145-150.
https://search.emarefa.net/detail/BIM-69443
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Wahhab, Abd al-Hadi A.. Frequent allelic losses at the short arm of chromosome 3p in invasive ductal carcinoma of breast in Egypt. Journal of the Egyptian National Cancer Institute. 2000. Vol. 12, no. 2, pp.145-150.
https://search.emarefa.net/detail/BIM-69443
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 149-150
رقم السجل
BIM-69443
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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