Effects of alcoholic extract of panax ginseng seeds and tamoxifen citrate drug on some fertility parameters and histopathological changes in testes of mice treated with doxorubicin

الملخص EN

The objective of this revision to examine the properties of panax gensing extract and tamoxifen citrate drug on fertility of male mice testes treated with Doxorubicin, the plant was extracted by using 70%ethanolic alcohol.

The mice were divided into five groups: The (T1) was given 300 mg / kg of extract, (T2) was given 150mg/kg of extract and 0.2mg/kg of Tamoxifen, (T3) was given Tamoxifen 0.4 mg/kg, (T4) was given distilled water.

Starting from one week, T1,T2 and T3 were intraperitoneally administered 0.15mg/kg of doxorubicin twice weekly for 5 week.

(T5) was treated 0.15mg/kg of doxorubicin twice weekly.

Results appeared the group given extract display important increase in motility index and turdidimetric analysis of sperms, and decrease in percentage of dead sperm and abnormalitites, the group treated with extract and tamoxifen citrate drug showed important decrease in percentage of dead sperm and abnormalities and important increase in turdidimetric analysis of sperms as compared with tamoxifen group.

The histopathological section of testis of doxorubicin group noticed severe degenerative changes in the wall of seminiferous tubules also atrophy in the spermatogonia and Sertoli cells, the section of extract group exhibited increase in number of spermatid and spermatozoa, the section of tamoxifen appeared edema in the interstitial tissue and congestion of blood vessels, the mix of panax gensing extract and tamoxifen citrate displayed decrease in redness of vessels and tissue.

From this revision established the extract of panax gensing seeds play important role in increase fertility of male mice by enhance spermatogenesis and have the ability to decrease side effect of tamoxifen citrate.