The possible cardio-protective effects of ethanolic artichoke extract against 5- fluorouracil induced cardiac toxicity in rats
العناوين الأخرى
الثأثير الوقائي المحتمل للمستخلص الإيثانول لنبات الأرض الشوكي ضد السمنة القلبية المستخدمة بعقار 5- فلوريديوراسيل في الجرذان
المؤلفون المشاركون
Najm, Safa Mustafa
Hamd, Maha Nuri
Numan, Intisar Tariq
Fadil, Ammar Amir
المصدر
Iraqi Journal of Pharmaceutical Sciences
العدد
المجلد 25، العدد 1 (30 يونيو/حزيران 2016)، ص ص. 1-5، 5ص.
الناشر
تاريخ النشر
2016-06-30
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Cardiac toxicity can occur during the therapy with several cytotoxic drugs, including 5- Fluorouracil (5- FU).
It is an antimetabolite that acts during the S phase of the cell cycle and is activated by thymidine phosphorylase into fluorodeoxyuridylate (5 fluoro 2'deoxyuridine 5'monophosphate, 5-FdUMP) that inhibits thymidylate synthase, thus preventing DNA synthesis that leads to imbalanced cell growth and ultimately cell death.
It is still a widely used anticancer drug, since 1957.
The present study aimed to evaluate the possible cardio-protective effects of ethanolic artichoke extract (Cynara scolymus L.) against 5-fluorouracil (5-FU) induced cardio-toxicity in rats by evaluating serum levels of Alanine aminotransferase, aspartate aminotransferase and creatine kinase enzymes.
Methods: Twenty -four female albino rats were randomly divided into 4 groups each group with 6 rats.
Group I: (negative control) received oral daily dose of dimethyl sulfoxide (DMSO) (2 ml/kg /day) for 10 successive days.
Group II: (positive control) received oral daily dose of DMSO (2 ml/kg /day) for 10 successive days and subsequently administered single dose of 5-FU (150 mg/kg) by intraperitoneal injection on 8th day in association with DMSO.
Groups III: received oral daily dose of ethanolic artichoke extract (200 mg/kg/day) for 10 successive days.
Groups IV: received oral daily dose of ethanolic artichoke extract (200 mg/kg/day) for 10 successive days with subsequently administered single intraperitoneal dose of 5-FU (150 mg/kg) on 8th day in association with ethanolic extract.
Results: Treatment of ethanolic artichoke extract prior 5-FU intoxication significantly attenuate the increase of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatine kinase (CK) enzymes activities caused by 5-FU-induced cardio-toxicity in rats.
Conclusions: Results of the present finding suggest that the ethanolic artichoke extract may be an effective modulator in mitigating 5-FU induced cardiac toxicity in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Numan, Intisar Tariq& Hamd, Maha Nuri& Fadil, Ammar Amir& Najm, Safa Mustafa. 2016. The possible cardio-protective effects of ethanolic artichoke extract against 5- fluorouracil induced cardiac toxicity in rats. Iraqi Journal of Pharmaceutical Sciences،Vol. 25, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-695790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Numan, Intisar Tariq…[et al.]. The possible cardio-protective effects of ethanolic artichoke extract against 5- fluorouracil induced cardiac toxicity in rats. Iraqi Journal of Pharmaceutical Sciences Vol. 25, no. 1 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-695790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Numan, Intisar Tariq& Hamd, Maha Nuri& Fadil, Ammar Amir& Najm, Safa Mustafa. The possible cardio-protective effects of ethanolic artichoke extract against 5- fluorouracil induced cardiac toxicity in rats. Iraqi Journal of Pharmaceutical Sciences. 2016. Vol. 25, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-695790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4-5
رقم السجل
BIM-695790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر