Synthesis of ciprofloxacin prodrug chitosan
المؤلفون المشاركون
Yasin, Ahmad
Rahi, Firas Aziz
Ali, Firyal Muhammad
المصدر
Journal of Babylon University : Journal of Applied and Pure Sciences
العدد
المجلد 24، العدد 3 (30 سبتمبر/أيلول 2016)، ص ص. 683-691، 9ص.
الناشر
تاريخ النشر
2016-09-30
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
In this research a new prodrug polymer was prepared by reaction of ciprofloxacin as acyl chloride derivative with chitosan as amino.
Polysaccharide gave new excellent biological properties and biomedical amide polymer Which could have potential use as a carrier for drug delivery system with ciprofloxacin formulation and evaluation of sustained release of ciprofloxacin prodrug chitosan was studied through amide attachment bond.
It has been evaluated for all the necessary parameters like concentration variation and in vitro drug release had been conducted successfully, when in contact with acidic gastric content and release from the dosage as in the stomach-controlled condition.
The prepared prodrug polymer was characterized by FTIR spectroscopy ,and UV spectroscopy ,physical properties were determined and intrinsic viscosity was measured .The good results were obtained as sustained release to prevent any side effect of ciprofloxacin with broad spectrum antibiotic .
The biological assay was conducted for prepared prodrug using.
The microorganism such as E.coli, staphylococcus aurous, the prepared prodrug appear high biological activity, compared with standard gentamycin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Firyal Muhammad& Rahi, Firas Aziz& Yasin, Ahmad. 2016. Synthesis of ciprofloxacin prodrug chitosan. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 24, no. 3, pp.683-691.
https://search.emarefa.net/detail/BIM-696597
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Firyal Muhammad…[et al.]. Synthesis of ciprofloxacin prodrug chitosan. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 24, no. 3 (2016), pp.683-691.
https://search.emarefa.net/detail/BIM-696597
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Firyal Muhammad& Rahi, Firas Aziz& Yasin, Ahmad. Synthesis of ciprofloxacin prodrug chitosan. Journal of Babylon University : Journal of Applied and Pure Sciences. 2016. Vol. 24, no. 3, pp.683-691.
https://search.emarefa.net/detail/BIM-696597
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 690-691
رقم السجل
BIM-696597
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر