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Lipoprotein (A), lipid profile and mean platelet volume in hypothyroid patients in Sana'a, Yemen : a case-control study
المؤلفون المشاركون
Adlat, Salah
Shamsan, Badriyah A.
al-Ariani, Ikram
المصدر
Yemeni Journal for Medical Sciences
العدد
المجلد 2016، العدد 10 (31 ديسمبر/كانون الأول 2016)9ص.
الناشر
تاريخ النشر
2016-12-31
دولة النشر
اليمن
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives : This study aimed to measure lipoprotein (a) [Lp(a)], lipid profile and mean platelet volume (MPV) in hypothyroid patients compared to healthy controls.
Methods : An unmatched case-control study was conducted involving 100 subjects (50 overt hypothyroidism patients and 50 healthy controls admitted to the University of Science and Technology Hospital, Al-Thawra Hos-pital and Al-Jomhori Hospital- Sana'a, Yemen during the period from May 2013 to March 2014.
Data were col-lected by in-person interview using a structured questionnaire followed by weight and height measurements.
Fresh blood samples were collected and analyzed using electrochemiluminescent, spectrophotometric and im-munoturbidimetric methods for estimating Lp(a), lipid profile and MPV parameters.
Results : Hypothyroid patients had a significantly higher concentration of Lp(a) compared to the control.
Total cholesterol (TC), triglycerides and low-density lipoprotein-cholesterol (LDL-C) levels were also significantly higher in hypothyroid patients.
Serum level of free triiodothyronine (FT3) was negatively correlated with Lp(a), TC and LDL-C (r = –0.380, p = 0.007; r = –0.354, p = 0.012; r = –0.350, p=0.013, respectively).
However, serum thy-roid-stimulating hormone was positively correlated with Lp(a), TC and LDL-C (r = 0.344, p = 0.015; r = 0.299, p = 0.035; r = 0.405, p=0.004, respectively) among hypothyroid patients.
MPV levels, on the other hand, showed a strong positive correlation with (r=0.611, p=0.001).
Conclusions : These findings indicate that overt hypothyroidism patients tend to have increased Lp(a) and ath-erogenic lipids that may contribute to increasing risk of atherosclerosis.
However, hypothyroid patients showed no significant difference compared to the controls regarding the MPV
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adlat, Salah& Shamsan, Badriyah A.& al-Ariani, Ikram. 2016. Lipoprotein (A), lipid profile and mean platelet volume in hypothyroid patients in Sana'a, Yemen : a case-control study. Yemeni Journal for Medical Sciences،Vol. 2016, no. 10.
https://search.emarefa.net/detail/BIM-698037
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adlat, Salah…[et al.]. Lipoprotein (A), lipid profile and mean platelet volume in hypothyroid patients in Sana'a, Yemen : a case-control study. Yemeni Journal for Medical Sciences No. 10 (2016).
https://search.emarefa.net/detail/BIM-698037
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adlat, Salah& Shamsan, Badriyah A.& al-Ariani, Ikram. Lipoprotein (A), lipid profile and mean platelet volume in hypothyroid patients in Sana'a, Yemen : a case-control study. Yemeni Journal for Medical Sciences. 2016. Vol. 2016, no. 10.
https://search.emarefa.net/detail/BIM-698037
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-698037
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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