Correlation of leptin with severity of plaque psoriasis in Iraqi male patients

الملخص EN

Background : psoriasis is a chronic inflammatory, immune mediated disease of the skin which is characterized by the presence of erythematous scaly plaques.

The prevalence of psoriasis is 2-4 % worldwide.

It has a negative impact on the patient’s health and may associate with serious medical comorbidities.

Objectives : to investigate the levels of leptin in male patients with plaque psoriasis and control group and their relationship with the clinical severity of psoriasis.

Methodology: the study was conducted on sixty male patients with plaque psoriasis and thirty healthy male individuals taken as a control group.

The sera obtained from blood were used to determine the levels of leptin in both groups.

Also, it was used to determine the correlation of leptin with severity of plaque psoriasis which measured by psoriasis area and severity index (PASI) score.

Leptin concentration was estimated by enzyme-linked immuno-sorbent assay (ELISA) method.

Results : the results of this work showed a significant increase (p < 0.05) of leptin concentrations in sera of plaque psoriasis compared to the control group.

Also, the results of linear regression analysis showed significant positive correlations of leptin with psoriasis area and severity index, i.e, PASI score.

Conclusion : the pro-inflammatory biomarker leptin is involved in pathogenesis of plaque psoriasis and may be used as markers for severity of disease.Recommendation: including a large sample size to confirm the association between leptin and severity of plaque psoriasis.