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Crucial roles of systemic and tissue lipid peroxidation levels and anti-oxidant defences following contrast agent application
المؤلفون المشاركون
Sitar, Gungor
Kucuk, Muhammad
Sitar, Mustafa Erinc
Yasar, Ozgur
Aydin, Seval
Yanar, Karolin
Cakatay, Ufuk
Buyukpınarbasili, Nur
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 18، العدد 6 (30 يونيو/حزيران 2016)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2016-06-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background : One of the most important side effects of contrast pharmaceutical agents, which are used very common in routine radiology practice, is contrast induced nephropathy.
Even ischemia, oxidative stress and osmolality related cytotoxic effects are considered, the molecular mechanisms underlying this pathology have not been identified completely yet.
Objectives : The aim of the current study was to reveal the role of oxidative stress and antioxidant enzymatic defence mechanisms in the aetiopathogenesis of contrast-induced nephropathy.
We also studied possible alleviating effects of N-acetylcysteine (NAC), a potent antioxidant, to obtain extra information regarding the molecular mechanisms underlying this pathology.
Materials and Methods : This is an clinical-experimental study, This study was conducted of Istanbul / Turkey between September 15, 2012 and April 15, 2013.
Three groups of male rats were randomly set up as a control group (C), a 100 mg/kg intraperitoneal NAC + 7 mL/kg contrast agent group (N + CIN) and a 7 mL / kg intraperitoneal contrast agent group (CIN).
They were placed in individual metabolic cages 48 hours after agent administration to obtain 24-hour urine samples.
Renal function tests (albumin, urea, creatinine, total protein) were conducted, oxidative stress parameters (Cu, Zn superoxide dismutase activity - Cu, Zn-SOD; advanced oxidation protein products - AOPP; protein carbonyls - PCO; total thiol groups - T-SH; and lipid hydroperoxides -LHP) were measured and tissues were analysed histopathologically.
Results : Compared with the control group, groups CIN and N + CIN had significantly higher urea and LHP levels (P < 0.05 and P < 0.001, respectively) and significantly lower Cu, Zn-SOD activity and creatinine clearance (P < 0.05).
There was no statistically significant difference between the groups in PCO or AOPP levels despite differences in descriptive statistics.
Conclusions : Contrast-agent-induced nephropathic changes are more closely related to the magnitude of lipid peroxidation than protein oxidation
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sitar, Gungor& Kucuk, Muhammad& Sitar, Mustafa Erinc& Yasar, Ozgur& Aydin, Seval& Yanar, Karolin…[et al.]. 2016. Crucial roles of systemic and tissue lipid peroxidation levels and anti-oxidant defences following contrast agent application. Iranian Red Crescent Medical Journal،Vol. 18, no. 6, pp.1-9.
https://search.emarefa.net/detail/BIM-701605
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sitar, Gungor…[et al.]. Crucial roles of systemic and tissue lipid peroxidation levels and anti-oxidant defences following contrast agent application. Iranian Red Crescent Medical Journal Vol. 18, no. 6 (Jun. 2016), pp.1-9.
https://search.emarefa.net/detail/BIM-701605
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sitar, Gungor& Kucuk, Muhammad& Sitar, Mustafa Erinc& Yasar, Ozgur& Aydin, Seval& Yanar, Karolin…[et al.]. Crucial roles of systemic and tissue lipid peroxidation levels and anti-oxidant defences following contrast agent application. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 6, pp.1-9.
https://search.emarefa.net/detail/BIM-701605
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-701605
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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