دور Rantes المصلي في الربو

الملخص EN

Asthma is chronic inflammatory disorder of the airways.

RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted) is an important chemotaxis in asthma.

This study aimed to measure serum RANTES in Syrian asthma patients.

Our study included 67 asthma patients (40 acute asthma patients and 27 stable asthma patients) and 21 healthy controls.

Serum RANTES and total IgE were assessed by ELISA.

Serum levels of RANTES and total IgE were significantly higher in acute asthma patients [(34288.16±16060.15pg/mL) (P<0.05),(476.46±265.08IU/mL) (P<0.05), respectively] compared to healthy controls [(2269.33±1594.49 pg/mL) (55.42±45.03 IU/mL), respectively] and stable asthma [(8010.09±7555.86 pg/mL)(299.74±206.58 IU/mL), respectively].

As conclusion, RANTES has important role in acute asthma more than in stable, subsequently has a role in asthmatic inflammatory mechanisms, so serum RANTES values may be used as a marker in clinical evaluation of asthma.