الوظيفة الكلوية لدى مرضى سوريين مصابين بالثلاسيمية بيتا الكبرى

الملخص EN

β-thalassemia major syndrome is a most common inherited anemia disorders in Syria.

It is caused by impaired β-globin chain synthesis leading to accumulation of unpaired α globin chain into erythrocyte precursors.

The patients with thalassemia major have severe anemia, along with tissue deposition of iron due to multiple blood transfusions, which is the main cause of multiple organ dysfunctions, especially in the cardiovascular, endocrine, renal and hepatic systems Our study aimed to evaluate the renal function in patients with beta thalassemia major, using conventional and early markers of renal dysfunctions and to correlate the findings with clinical parameters (age, period of treatment with blood transfusion and serum ferritin) and iron status.

170 β-thalassemia major patients (aged 4-28 years) and 30 healthy controls (aged 4-28 years) were enrolled in this study.

Blood samples were collected and serum was separated for measurement of creatinine, urea and ferritin.

Urine samples were also collected for measurement of creatinine and albumin, and an Albumin: Creatinine ratio (mg/g) were calculated.

Our results showed significant increase in urine Albumin: Creatinine ratio (A:C ratio) and serum creatinine in beta thalassemia patients comparing with controls(p<0.0001 and 0.017, respectively).

On the other hand, there were no significant difference in serum urea levels between beta thalassemia patients and controls (p=0.480).

In thalassemia patients, Albumin: Creatinine ratio showed significant positive correlation with period of treatment with blood transfusion and age.

As a conclusion, this study suggest that renal dysfunction are common complications in Syrian patients with beta thalassemia major, without clinical manifestations of renal dysfunction.