Relationship between interleukin-1 receptor antagonist and,c-peptide in children with type 1 diabetes mellitus
العناوين الأخرى
العلاقة بين مضاد مستقبلة الإنترولوكين-1 وسي ببتد في الأطفال الذين يعانون من مرضى البول السكري النوع الأول
المصدر
العدد
المجلد 17، العدد 63 (30 يونيو/حزيران 2014)، ص ص. 17-22، 6ص.
الناشر
جامعة عين شمس كلية الدراسات العليا للطفولة
تاريخ النشر
2014-06-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background: Type 1 diabetes is an immune-mediated disease leading to selective destruction of insulin-producing -cells in which cytokines play an important role.
Cytokines related to the innate immune response, such as interleukin (IL)- 1, IL-1 receptor antagonist (IL-1ra), and tumor necrosis factor (TNF)- are thought to be associated with -cell destruction and disease status in humans and in animal models.
Objective: This prospective case-control study was carried out to assess the association of C-peptide as a marker of -cell function with systemic cytokine IL-1ra concentration during the first 6 months after diagnosis in children with type 1 diabetes.
Methods: Thirty children with newly diagnosed type 1 diabetes with a mean age of (6.5± 2.2) years and thirty age and sex matched healthy children included as controls were enrolled in this study.
Fasting and stimulated C-peptide and circulating concentration of IL-1ra were determined at time of diagnosis in the serum of patients and controls and 6 months after diagnosis in the serum of the patients only using ELISA technique.
Results: Diabetic patients showed significantly lower mean serum fasting C-peptide (0.5± 0.3) ng/mL, lower mean serum stimulated C-peptide (0.7± 0.2) ng/mL and lower mean serum IL-1ra (202.6± 55.8) pg/mL compared to control group (1.4± 0.2) ng/mL, (2.2± 0.3) ng/mL, and (235.0± 29.5) pg/mL respectively at time of presentation.
There was no statistically significant correlation between IL-1ra and fasting C-peptide or stimulated C-peptide neither at time of diagnosis nor 6 months after diagnosis (P>0.05).
Conclusion: The present study concluded there was no significant correlation between C-peptide (as a marker of -cell function) and IL-1ra (the natural antagonist IL-1) in children with recent onset type 1 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Din, Majdi& al-Samihi, Muna H.& al-Shamawi, Iman A.& Farid, Samir M.& Tawfiq, Sawsan M.& Yunus, Iman R.…[et al.]. 2014. Relationship between interleukin-1 receptor antagonist and,c-peptide in children with type 1 diabetes mellitus. Journal of Childhood Studies،Vol. 17, no. 63, pp.17-22.
https://search.emarefa.net/detail/BIM-703376
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yunus, Iman R.…[et al.]. Relationship between interleukin-1 receptor antagonist and,c-peptide in children with type 1 diabetes mellitus. Journal of Childhood Studies Vol. 17, no. 63 (Apr. / Jun. 2014), pp.17-22.
https://search.emarefa.net/detail/BIM-703376
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Din, Majdi& al-Samihi, Muna H.& al-Shamawi, Iman A.& Farid, Samir M.& Tawfiq, Sawsan M.& Yunus, Iman R.…[et al.]. Relationship between interleukin-1 receptor antagonist and,c-peptide in children with type 1 diabetes mellitus. Journal of Childhood Studies. 2014. Vol. 17, no. 63, pp.17-22.
https://search.emarefa.net/detail/BIM-703376
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 21
رقم السجل
BIM-703376
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر