Hepatoprotective Effect of Matricaria chamomilla Hot Aqueous Extract Against Methomyl 90 %-Induced Hepatotoxicity In Mice

الملخص EN

The effect of orally feeding of hot liquid extract of (Matricaria chamomilla flowers) on hepatotoxicity induced to male mice by methomyl ,S-methyl-1-N-[(methylcarbamoyl)oxy]thioacetimidate (IUPAC) was investigated for( 30 days).

These effects could be explored by measuring any changings in the weight of both body and liver.Histopathological examination of liver has been performed also along with aspartate aminotransferase(ALAT) and alanine aminotransferase (ASAT) levels in serum.

The results showed that the poisoned group treated with pesticide by using two doses of hot aqueous extract of chamomile (5 and 7) mg / kg of body weight have shown a marked improvement of the symptoms of pesticide poisoning, compared with the positive control group of the pesticide and that the dose of the methomyl 90% led to the toxic effects appeared by decreasing in body weights in mice and noticeable changes in liver tissue accompanied by increasing in its weight.There was significant increasing in the level of liver enzymes (ASAT, ALAT), Histopathological examination of liver sections of mice administered Matricaria chamomilla hot aqueous extract demonstrated reduction of damaged liver tissue induced by methomyl 90%.Current study reveals that hot aqueous extract of Matricaria chamomilla promises protection for hepatocytes against methomyl 90%- hepatotoxic mice induction.

Finally,this study recommends that intake of hot aqueous extract of Matricaria chamomilla could be useful for liver disorders