Whole-exome sequencing reveals a recurrent mutation in the cathepsin C gene that causes Papillon-lefevre syndrome in a Saudi family

الملخص EN

Bacterial infections are among the major cause of morbidity and mortality worldwide.

The present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of five Cameroonian edible plants namely Colocasia esculenta, Triumfetta pentandra, Hibiscus esculentus, Canarium schweinfurthii and Annona muricata against a panel of 19 multidrug resistant Gram-negative bacterial strains.

The liquid broth microdilution was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts.

The preliminary phytochemical screening of the extracts was conducted according to the standard phytochemical methods.

Results showed that all extracts contained compounds belonging to the classes of polyphenols, triterpenes and steroids, other classes of chemicals being selectively distributed.

Canarium schweinfurthii extract showed the best activity with MIC values ranging from 64 to 1024 lg/mL against 89.5% of the 19 tested bacteria strains.

MIC values below or equal to 1024 lg/mL were also recorded with Triumfetta pentandra, Annona muricata, Colocasia esculenta and Hibiscus esculentus extracts respectively against 15/19 (78.9%), 11/19 (57.9%), 10/19 (52.6%) and 10/19 (52.6%) tested bacteria.

Extract from C.

schweinfurthii displayed the lowest MIC value (64 lg/mL) against Escherichia coli AG100ATet.

Finally, the results of this work provide baseline information for the use of C.

esculenta, T.

pentandra, H.

esculentus, C.

schweinfurthii and A.

muricata in the treatment of bacterial infections including multidrug resistant phenotypes.

ھ 2015 The Authors.

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This is an open access article under theCCBY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).