The effect of cumin cyminum l. plus lime administration onweight loss and metabolic status in overweight subjects : a randomized double-blind placebo-controlled clinical trial

الملخص EN

Background: Limited data are available regarding the effects of combined administration of Cumin cyminum L.

and lime on weight loss and metabolic profiles among subjects with overweight subjects.

Objectives: The current study aimed to assess the effects of combined administration of Cumin cyminum L.

and lime on weight loss and metabolic profiles among subjects with overweight.

Patients and Methods: This randomized double-blind placebo-controlled clinical trial was conducted on 72 subjects with overweight, aged 18 - 50 years old.

Participants were randomly divided into three groups: Group A received high-dose Cumin cyminum L.

and lime capsules (75 mg each, n = 24), group B low-dose Cumin cyminum L.

and lime capsules (25 mg each, n = 24) and group C placebos (n = 24) twice daily for eight weeks.

Results: After eight weeks of intervention, compared with low-doseC.

cyminumL.

plus lime and placebo, taking high-doseC.

cyminum L.

plus lime resulted in significant weight loss (in the high-dose group: -2.1±1.7 vs.

in the low-dose group: -1.2±1.5 and in the placebo group: + 0.2 ± 1.3 kg, respectively; P < 0.001) and body mass index (-0.8 ± 0.6 vs.

-0.5 ± 0.5 and +0.1 ± 0.5 kg/m2 , respectively; P < 0.001).

In addition, administration of high-doseC.

cyminum L.

plus lime compared with low-doseC.

cyminum L.

plus lime and placebo, led to a significant reduction in fasting plasma glucose (FPG) (P < 0.001) and a significant rise in quantitative insulin sensitivity check index (QUICKI) (+ 0.02 ± 0.02 vs.

+ 0.01 ± 0.02 and 0.01 ± 0.01, respectively; P = 0.01).

Moreover, a significant decrease in serum triglycerides (-14.1 ± 56.2 vs.

+13.9 ± 36.8 and + 10.6 ± 25.1 mg/dL; respectively; P = 0.03), total-cholesterol (-18.4 ± 28.6 vs.

+8.6 ± 28.5 and -1.0 ± 24.8 mg/dL; respectively; P = 0.004) and low density lipoproteins- (LDL)-cholesterol levels (-11.8 ± 20.7 vs.

+6.5 ± 23.2 and -2.9 ± 20.4 mg/dL, respectively; P = 0.01) was observed following the consumption of high-dose C.

cyminum L.

plus lime compared with low-dose C.

cyminum L.

plus lime and placebo.

Conclusions: Results of the current study indicated that taking high-dose C.

cyminum L.

plus lime for eight weeks among subjects with overweight had beneficial effects on weight, BMI, FPG, QUICKI, triglycerides, total-cholesterol and LDL-cholesterol levels.