Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma : relationship with clinicopathological parameters
المؤلفون المشاركون
Hafiz, Nisrin H.
Tahun, Nifin S.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 28، العدد 3 (30 سبتمبر/أيلول 2016)، ص ص. 149-156، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2016-09-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background : Gastric cancer is one of the most common cancers and the second most common cause of cancer-related death worldwide.
Identification of specific prognostic indicators might allow a better prognostic stratification and more effective therapy.
Aim : To assess the expression and relationship between COX-2 and VEGF protein in gastric adenocarcinoma and whether these markers are useful in predicting clinicopathological prognostic parameters.
Materials and methods : The study included 83 formalin-fixed paraffin embedded tissue samples of excised gastric adenocarcinoma and 20 non tumorous tissue controls.
The slides were subjected to COX-2 and VEGF immunohistochemical staining using a streptavidin–biotinperoxidase according to the manufacturer’s protocol.
The results were assessed independently by two pathologists.
The relationships among COX-2 and VEGF expression and clinicopathological parameters were statistically analyzed.
Results: COX-2 and VEGF expressions were obviously higher in carcinoma tissues compared to normal mucosae (p < 0.001).
The expression rate of COX-2 was 54.2 % and of VEGF was 68.7 %.
COX-2 positive tumors were significantly correlated with Lauren classification, tumor depth and Helicobacter pylori infection (p < 0.001, p = 0.008, p = 0.035).
VEGF was significantly associated with lymph node metastasis and tumor depth (p<0.001).
There was a positive association between VEGF and COX-2 expression in gastric adenocarcinoma (Kappa value = 0.55).
Conclusion : In gastric adenocarcinoma, COX-2 expression might serve as a powerful indicator for intestinal type carcinoma, locally advanced disease and H.
pylori infection, while VEGF was related to loco-regional progression.
COX-2 might be involved in the development of angiogenesis in gastric carcinoma through VEGF upregulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hafiz, Nisrin H.& Tahun, Nifin S.. 2016. Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma : relationship with clinicopathological parameters. Journal of the Egyptian National Cancer Institute،Vol. 28, no. 3, pp.149-156.
https://search.emarefa.net/detail/BIM-708857
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hafiz, Nisrin H.& Tahun, Nifin S.. Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma : relationship with clinicopathological parameters. Journal of the Egyptian National Cancer Institute Vol. 28, no. 3 (Sep. 2016), pp.149-156.
https://search.emarefa.net/detail/BIM-708857
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hafiz, Nisrin H.& Tahun, Nifin S.. Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma : relationship with clinicopathological parameters. Journal of the Egyptian National Cancer Institute. 2016. Vol. 28, no. 3, pp.149-156.
https://search.emarefa.net/detail/BIM-708857
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 156
رقم السجل
BIM-708857
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر