دراسة العلاقة بين مستويات عامل النمو و التمايز-15 البلازمية و النهاية الأمينية للببتيد الدماغي المدر للصوديوم NTproBNP و فشل القلب

الملخص EN

Heart failure is a complex clinical syndrome, that can result from any structural or functional cardiac disorder, that impairs the ability of the ventricles to fill with or eject blood.

It is the common end of many disorders.

The causes of heart failure range from malfunction of the heart valves to infections of the heart muscle to diseases of the bones and blood.

It characterized by signs and symptoms of intravascular and interstitial volume overload, including shortness of breath, rales, and edema, or manifestations of inadequate tissue perfusion, such as fatigue or poor exercise tolerance.

GDF-15 is antihypertrophy marker, and ventricular hypertrophy is a common manifestation of heart failure.

We determined plasma GDF-15, NTproBNP, of study groups [heart failure (n=112) divided according to NYHA classification NYHA II, III, IV, controls (n=25), dyspnea (n=21)] by ELISA.

We found that their levels in patients were high in comparison to controls.

Our study revealed that plasma GDF-15 & NTproBNP increase in heart failure patients.