β-catenin expression and its relation to bryne’s invasive grading system in oral squamous cell carcinoma
المؤلفون المشاركون
Muhammad, Dina Nazim
Hamid, Marwah Abd al-Salam
Gharib, Balqis Taha
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 28، العدد 3 (30 سبتمبر/أيلول 2016)، ص ص. 52-58، 7ص.
الناشر
تاريخ النشر
2016-09-30
دولة النشر
العراق
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background : Invasion in oral cancer involves alterations in cell-cell and cell-matrix interactions that accompanied by loss of cell adhesion.
Catenins stabilize cellular adherence junctions by binding to E-cadherin, which further mediates cell-cell adhesion and regulates proliferation and differentiation of epithelial cells.
The Wnt/β-catenin pathway is one of the major signaling pathways in cell proliferation, oncogenesis, and epithelial-mesenchymal transition.
Aims of the study : to detect immunohistochemical distribution pattern and different subcellular localization of β-catenin in oral squamous cell carcinoma and relate such expression to Bryne’s invasive grading system.
Materials and Methods : This study included 30 paraffin blocks of primary oral squamous cell carcinoma.
Bryne’s grading performed on routein stained slides.
Immunohistochemical staining for anti β-catenin was done to illustrate its pattern and subcellular localization in malignant cells.
The expression correlated with the invasive grading system.
Results : β-catenin expression detected in all sample (100 %).
It was (23.3 %) membranous, (60 %) aberrant cytoplasmic and (16.7 %) mixed expression.
Diffuse strong homogeneous pattern was observed in (40%) of the cases.
The cytoplasmic expression had significant high mean rank in score 3, diffuse strong homogeneous pattern and strong intensity.
Well-differentiated carcinoma expressed great mixed membranous/cytoplasmic expression while poordifferentiated cases showed low membranous mean rank expression.
The strong diffuse homogeneous pattern with strong staining was significantly frequent in well-differentiated squamous cell carcinoma.
Conclusion : Increase cytoplasmic β-catenin expression is parallel with carcinoma dedifferentiation.
Suggesting maintenance of its adhesive role with the inhibition of the normal degradation of free β-catenin in the cytoplasm, which might cause accelerated tumor cell proliferation
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hamid, Marwah Abd al-Salam& Gharib, Balqis Taha& Muhammad, Dina Nazim. 2016. β-catenin expression and its relation to bryne’s invasive grading system in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry،Vol. 28, no. 3, pp.52-58.
https://search.emarefa.net/detail/BIM-709319
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hamid, Marwah Abd al-Salam…[et al.]. β-catenin expression and its relation to bryne’s invasive grading system in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry Vol. 28, no. 3 (Sep. 2016), pp.52-58.
https://search.emarefa.net/detail/BIM-709319
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hamid, Marwah Abd al-Salam& Gharib, Balqis Taha& Muhammad, Dina Nazim. β-catenin expression and its relation to bryne’s invasive grading system in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry. 2016. Vol. 28, no. 3, pp.52-58.
https://search.emarefa.net/detail/BIM-709319
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 57-58
رقم السجل
BIM-709319
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر