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Association of exon 9 FGFR3 mutations and cancer grads in patients with bladder cancer
المؤلفون المشاركون
al-Faysal, Abd al-Husayn Muwayt
Bresam, Sabah
المصدر
Iraqi Journal of Biotechnology
العدد
المجلد 15، العدد 2 (31 ديسمبر/كانون الأول 2016)، ص ص. 109-118، 10ص.
الناشر
جامعة بغداد معهد الهندسة الوراثية و التقنيات الإحيائية للدراسات العليا
تاريخ النشر
2016-12-31
دولة النشر
العراق
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Bladder cancer is the ninth most common cancer diagnosis worldwide, with more than 330,000 new cases each year and more than 130,000 deaths per year, with an estimated male: female ratio of 3.8:1.0.
According to the most recent Iraqi cancer record (Iraqi cancer registry, 2010), bladder carcinoma is currently ranks sixth among the commonest ten cancers.
Previous studies indicated that genetic alterations were involved in bladder cancer.
To detect genetic alteration in exon 9 of FGFR3 gene, 50 patients with different grads of bladder cancer who admitted to Ghazi AL-Hariri Hospital in Baghdad and 25 healthy persons aged between 30 to 86 years were included in this study.
DNA was extracted from blood samples from patients and healthy control.
PCR was conducted using special primers.
Mutations of exon 9 of the FGFR3 gene were screened by sequencing and the patients sequencing results were compared with human reference FGFR3 gene sequence (NCBI Reference Sequence: NG_012632.1).
Among 50 patients included in this study, 30 (37%) patients were with mutations detected in exon 9 which include novel g.16026 del G and g.16024 sub G>C mutations.
The more frequent mutation was g.16026 del G (22, 70%) followed by g.16024 sub G>C mutation (8, 30%).
Moreover, the results showed that three patients were with compound mutations (with both exon 9 mutations).
Exon 9 mutations (g.16024 sub G to C and g.16026 del G) showed an association with cancer initiation and metastasis since they detected in grad I and II.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Faysal, Abd al-Husayn Muwayt& Bresam, Sabah. 2016. Association of exon 9 FGFR3 mutations and cancer grads in patients with bladder cancer. Iraqi Journal of Biotechnology،Vol. 15, no. 2, pp.109-118.
https://search.emarefa.net/detail/BIM-709497
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Faysal, Abd al-Husayn Muwayt& Bresam, Sabah. Association of exon 9 FGFR3 mutations and cancer grads in patients with bladder cancer. Iraqi Journal of Biotechnology Vol. 15, no. 2 (2016), pp.109-118.
https://search.emarefa.net/detail/BIM-709497
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Faysal, Abd al-Husayn Muwayt& Bresam, Sabah. Association of exon 9 FGFR3 mutations and cancer grads in patients with bladder cancer. Iraqi Journal of Biotechnology. 2016. Vol. 15, no. 2, pp.109-118.
https://search.emarefa.net/detail/BIM-709497
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 116-118
رقم السجل
BIM-709497
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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