Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients

المؤلفون المشاركون

Sahtut, Wisal
Juydri, Yusra
Dama, Najla K.
Toumi, Melek
Azabi, Awatif
Mrabet, Sinda
Nouira, Safa
Saidan, Dalila
Amur, Samirah
Belarbia, Anis
Zellama, Dorsaf
Ashur, Abd al-Latif

المصدر

Saudi Journal of Kidney Diseases and Transplantation

العدد

المجلد 27، العدد 6 (31 ديسمبر/كانون الأول 2016)، ص ص. 1194-1199، 6ص.

الناشر

المركز السعودي لزراعة الأعضاء

تاريخ النشر

2016-12-31

دولة النشر

السعودية

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Peritoneal protein loss is one of the inevitable consequences during continuous ambulatory peritoneal dialysis (CAPD).

Our objective was to study the effect of sulodexide on the protein loss and efficiency of dialysis.

This study included six patients receiving CAPD treated with sulodexide at the dose of 600 IU/day given by intraperitoneal injection for 10 days.

Clinical and biologic parameters were assessed before starting the treatment (D0) and after 10 days of treatment (D10).

We also evaluated the benefit of therapy persisting 20 days after the end of treatment (D30).

The sulodexide administration produced a significant improvement of the peritoneal function as determined by a significant increase in the following ratios measured at the 4 th h of dwell time on D0 and D30: dialysate-to plasma (D/P) creatinine from 0.63 ± 1.45 to 0.85 ± 0.073 (P = 0.028) and D/P urea from 0.63 ± 0.15 to 79 ± 0.2 (P = 0.048).

A significant decrease of albumin leakage was observed, which was 0.90 ± 0.40 g/L at baseline, 0.67 ± 0.36 g/L on the 10th day, and 0.43 ± 0.22g/L 20 days after the end of treatment.

Within 10-day treatment period, use of sulodexide resulted in a reduction in the peritoneal loss of albumin, in addition to improvement of the quality of dialysis and the residual renal function among these patients.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Juydri, Yusra& Dama, Najla K.& Toumi, Melek& Sahtut, Wisal& Azabi, Awatif& Ashur, Abd al-Latif…[et al.]. 2016. Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 6, pp.1194-1199.
https://search.emarefa.net/detail/BIM-717271

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ashur, Abd al-Latif…[et al.]. Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 6 (Nov. / Dec. 2016), pp.1194-1199.
https://search.emarefa.net/detail/BIM-717271

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Juydri, Yusra& Dama, Najla K.& Toumi, Melek& Sahtut, Wisal& Azabi, Awatif& Ashur, Abd al-Latif…[et al.]. Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 6, pp.1194-1199.
https://search.emarefa.net/detail/BIM-717271

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 1198-1199

رقم السجل

BIM-717271