Synthesis, characterization and in vitro drug release of cisplatin loaded Cassava starch acetate–PEG gelatin nanocomposites

المؤلفون المشاركون

Prabha, G.
Raj, V. Samuel

المصدر

Arab Journal of Basic and Applied Sciences

العدد

المجلد 21، العدد 0 (31 أكتوبر/تشرين الأول 2016)، ص ص. 10-16، 7ص.

الناشر

جامعة البحرين كلية العلوم

تاريخ النشر

2016-10-31

دولة النشر

البحرين

عدد الصفحات

7

التخصصات الرئيسية

الكيمياء

الموضوعات

الملخص EN

The aim of the present study is to examine the feasibility of Cassava starch acetate (CSA)–polyethylene glycol (PEG)–gelatin (G) nanocomposites as controlled drug delivery systems.It is one of the novel drug vehicles which can be used for the controlled release of an anticancer drug.

Simple nano precipitation method was used to prepare the carriers CSA–PEG–G nanocom-posites and they were used for entrapping cisplatin (CDDP).

Through FT-IR spectroscopy, the linking among various components of the system was proved and with the help of scanning electron microscope and transmission electron microscopy (TEM), the surface morphology was investigated.

The particle sizes of the CSA–CDDP, CSA–CDDP–PEG and CSA–CDDP–PEG–G polymer com-posites were between 140 and 350 nm, as determined by a Zetasizer.

Drug encapsulation efficiency, drug loading capacity and in vitro release of CDDP were evaluated respectively.

The findings revealed that the cross linked CSA–PEG–G nanocomposites can be a potential polymeric carrier for controlled delivery of CDDP.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Raj, V. Samuel& Prabha, G.. 2016. Synthesis, characterization and in vitro drug release of cisplatin loaded Cassava starch acetate–PEG gelatin nanocomposites. Arab Journal of Basic and Applied Sciences،Vol. 21, no. 0, pp.10-16.
https://search.emarefa.net/detail/BIM-717722

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Raj, V. Samuel& Prabha, G.. Synthesis, characterization and in vitro drug release of cisplatin loaded Cassava starch acetate–PEG gelatin nanocomposites. Arab Journal of Basic and Applied Sciences Vol. 21 (Oct. 2016), pp.10-16.
https://search.emarefa.net/detail/BIM-717722

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Raj, V. Samuel& Prabha, G.. Synthesis, characterization and in vitro drug release of cisplatin loaded Cassava starch acetate–PEG gelatin nanocomposites. Arab Journal of Basic and Applied Sciences. 2016. Vol. 21, no. 0, pp.10-16.
https://search.emarefa.net/detail/BIM-717722

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 15-16

رقم السجل

BIM-717722