دراسة مستويات الغلوتاثَيون و المالونديالدهيد لدى مرضى مصابين بالكيسة العدارية

الملخص EN

The larva of Echinococcus granulosus causes hydatid cyst in human.

The oxidative stress results by defends of immune system cells against parasites.

In this mechanism, various oxidant molecules as free radicals, affects the cell membrane, resulting lipid peroxidation and forming of malondialdhyde (MDA) (marker of the oxidative stress).

Glutathione (GSH) plays role as antioxidant and reacts with free radicals.

The aim of this study is to assay the levels of glutathione (GSH) and malondialdhyde (MDA) in the plasma of patients diagnosed with hydatid cyst, to investigate the incidence of oxidative stress.

Our study group comprised 101 patients, who diagnosed with hydatid cyst, 35 healthy subjects who were negative for hydatid cyst by indirect hemaggltination (control group).

The GSH levels was assayed by kinetics colorimetric method, and the MDA levels was assayed by colorimetric method.

We observed an increase in the MDA levels and decrease in the GSH levels in patients with hydatid cyst compared with control group.

This results mean the the incidence of the oxidative stress in patients.

Also, we observed a reverse correlation between GSH levels and MDA levels in patients group, this means correlation between the oxidative stress and retraction of GSH in the cells.