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The effects of monosodium glutamate and tannic acid on adult rats
المؤلفون المشاركون
Calis, Ibrahim Ugur
Cosan, Didem Turgut
Saydam, Faruq
Kolac, Umut Kerem
Soyocak, Ahu
Kurt, Hulyam
Gunes, Hasan Veysi
Sahinturk, Varol
Mutlu, Fezan Sahin
Koroglu, Zaynab Ozdemir
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 18، العدد 10 (31 أكتوبر/تشرين الأول 2016)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2016-10-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background : Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods.
The excessive use of MSG has been shown to increase oxidative stress in different organ systems and causes glucose metabolism disorders, obesity, and coronary diseases.
Objectives : In this study, the antioxidant activity of tannic acid was investigated experimentally with respect to its protective effects against overdosed MSG-induced oxidative stress in rats.
The study took place in Turkey in August 2013.
Methods : Four groups (n = 7) of three- to four-month-old Sprague-Dawley female rats were used in this study.
The first group was the control, who were administered saline.
The second group received tannic acid (50 mg/kg, 3 days) intraperitoneally (i.p.).
The third group received MSG (2 g / kg, 7 days) i.p., and the fourth group received both tannic acid (50 mg / kg, 3 days, pretreatment) and MSG (2 g/kg, 7 days) i.p.
The animals were euthanized ten days later.
Blood was collected for determining the hematological values and blood glucose levels.
Superoxide dismutase (SOD)andmalondialdehyde(MDA)levels were determined in the brain, liver, andkidney homogenates, and in the erythrocyte hemolysate.
Histopathological examination of the brain, liver, and kidneys was conducted through hematoxylin-eosin staining.
Results : The data showed that the tannic acid treatment statistically decreased the MDA levels in the brain tissues of the group administered MSG and tannic acid (P < 0.001) when compared to the corresponding values of the control group.
The SOD activities in the blood hemolysates of theMSGandtannic acidgroupincreasedwhencomparedto the corresponding values for theMSGgroup (P < 0.01).
Additionally, we found that pretreatment with tannic acid reduced blood glucose levels in comparison to the levels of the MSG group (P = 0.029).
The results of our study show that tannic acid pretreatment in adult rats decreased blood glucose levels and oxidative stress.
Conclusions: In the literature, it was observed that short-term MSG exposure does not cause significant histological changes in the kidneys, liver, or brain cortex.
These findings should be re-evaluated in additional long-term studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Calis, Ibrahim Ugur& Cosan, Didem Turgut& Saydam, Faruq& Kolac, Umut Kerem& Soyocak, Ahu& Kurt, Hulyam…[et al.]. 2016. The effects of monosodium glutamate and tannic acid on adult rats. Iranian Red Crescent Medical Journal،Vol. 18, no. 10, pp.1-7.
https://search.emarefa.net/detail/BIM-724419
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Calis, Ibrahim Ugur…[et al.]. The effects of monosodium glutamate and tannic acid on adult rats. Iranian Red Crescent Medical Journal Vol. 18, no. 10 (Oct. 2016), pp.1-7.
https://search.emarefa.net/detail/BIM-724419
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Calis, Ibrahim Ugur& Cosan, Didem Turgut& Saydam, Faruq& Kolac, Umut Kerem& Soyocak, Ahu& Kurt, Hulyam…[et al.]. The effects of monosodium glutamate and tannic acid on adult rats. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 10, pp.1-7.
https://search.emarefa.net/detail/BIM-724419
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7
رقم السجل
BIM-724419
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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