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Histological and biochemical study of Nigella Sativa seeds effects on liver of male albino rats treated with rifampicin
العناوين الأخرى
دراسة نسبية و كيموحيوية لتأثير بذور الحبة السوداء على كبد ذكور الجرذان البيض المعاملة بالريفامبسين
المؤلفون المشاركون
Barraj, Abd Hasan
al-Azzawi, Adnan Fayyd Samir
المصدر
العدد
المجلد 57، العدد 4C (31 ديسمبر/كانون الأول 2016)، ص ص. 2829-2839، 11ص.
الناشر
تاريخ النشر
2016-12-31
دولة النشر
العراق
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Rifampicin (RF) considered a hepatotoxic drug.
Is one of the first line successful drugs of management of tuberculosis.
To reduce injury and protect liver from adverse effect of Rifampicin, this study was designed to investigate the activity of Nigella Sativa (NS) seeds powder aqueous suspension to hepato protection against Rifampicin.
For conducting this study, 24 male albino rats were divided into four groups and all treated orally as follow; group І (control), received normal saline alone; group II, received RF (50mg/kg body weight/day); group III received NS it's called normal dose, (2g / kg body weight day); group IV RF (50mg/kg body weight) + NS (2g / kg body weight).Respectively for 28 days.
Blood samples obtained for estimation of liver foundation parameters and enzymes such as serum alkaline phosphate (ALP), serum glutamic pyruvic transaminase (SGPT), serum glutamic Oxaloacetic transaminase (SGOT) and serum bilirubin.
After rats were scarified, liver tissue sections were prepared for histopathological examination.
The results parameters in treated rats in group II showed a significant (P < 0.05) increase, while group IV showed a significant (P < 0.05) decrease in biochemical parameters of liver.
Liver histopathological examination of animal group treated with RF showed focal necrotic area in the hepatocyte and neutrophils and mononuclear cells aggregation in thickening wall of congested blood vessels with large granulomatous lesion in liver Parenchyma.
The Histological examination of pre-treatment animal group of NS (2g / kg body weight) showed near normal liver architecture with moderate aggregation of mononuclear cell around blood vessels and moderate proliferation of kupffer cells.
Pre-treatment of NS produced significant hepatoprotection by decreasing the levels of ALP, SGOT, SGPT and bilirubin.
The result indicates clearly that NS possesses hepatoprotective and activity against RF induced hepato toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Azzawi, Adnan Fayyd Samir& Barraj, Abd Hasan. 2016. Histological and biochemical study of Nigella Sativa seeds effects on liver of male albino rats treated with rifampicin. Iraqi Journal of Science،Vol. 57, no. 4C, pp.2829-2839.
https://search.emarefa.net/detail/BIM-733973
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Azzawi, Adnan Fayyd Samir& Barraj, Abd Hasan. Histological and biochemical study of Nigella Sativa seeds effects on liver of male albino rats treated with rifampicin. Iraqi Journal of Science Vol. 57, no. 4C (2016), pp.2829-2839.
https://search.emarefa.net/detail/BIM-733973
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Azzawi, Adnan Fayyd Samir& Barraj, Abd Hasan. Histological and biochemical study of Nigella Sativa seeds effects on liver of male albino rats treated with rifampicin. Iraqi Journal of Science. 2016. Vol. 57, no. 4C, pp.2829-2839.
https://search.emarefa.net/detail/BIM-733973
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Text in English ; abstracts in English and Arabic.
رقم السجل
BIM-733973
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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