Aminoglycoside induced ototoxicity associated with mitochondrial DNA mutations

المؤلفون المشاركون

Takin, Mustafa
Joseph Foster I. I.

المصدر

The Egyptian Journal of Medical Human Genetics

العدد

المجلد 17، العدد 3 (31 يوليو/تموز 2016)، ص ص. 287-293، 7ص.

الناشر

الجمعية المصرية للأمراض الوراثية

تاريخ النشر

2016-07-31

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

العلوم الطبية والصيدلة والعلوم الصحية

الملخص EN

Despite the risk of permanent ototoxic effects, aminoglycosides remain commonly utilized antibiotics worldwide due to low cost and efficiency in treating severe infections.

Over the last two decades, mitochondrial mutations have been shown to enhance the likelihood of ototoxic injury.

In particular the 1555A>G mutation in the mitochondrial gene MTRNR1 has been strongly associated with the onset of aminoglycoside-induced deafness; though pinning down the exact mechanism of action has thus far been elusive.

Clinically aminoglycoside-induced deafness has been characterized by variation in the degree of hearing loss, which has prompted an investigation into genetic modifiers.

To date, several putative mutations have been categorized as contributing factors to the onset of deafness with no single variation being sufficient to bring about hearing loss.

Meanwhile current methods to mitigate the risk of ototoxic injury are in various stages of development.

Efforts to alter the molecular structure of aminoglycosides have shown a potential path to reducing ototoxicity while preserving antibacterial properties, but these drugs are not clinically available.

On the other hand, application of preemptive audiometry provides the most readily available method to both monitor and reduce the extent of aminoglycoside-induced deafness.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Joseph Foster I. I.& Takin, Mustafa. 2016. Aminoglycoside induced ototoxicity associated with mitochondrial DNA mutations. The Egyptian Journal of Medical Human Genetics،Vol. 17, no. 3, pp.287-293.
https://search.emarefa.net/detail/BIM-734019

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Joseph Foster I. I.& Takin, Mustafa. Aminoglycoside induced ototoxicity associated with mitochondrial DNA mutations. The Egyptian Journal of Medical Human Genetics Vol. 17, no. 3 (Jul. 2016), pp.287-293.
https://search.emarefa.net/detail/BIM-734019

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Joseph Foster I. I.& Takin, Mustafa. Aminoglycoside induced ototoxicity associated with mitochondrial DNA mutations. The Egyptian Journal of Medical Human Genetics. 2016. Vol. 17, no. 3, pp.287-293.
https://search.emarefa.net/detail/BIM-734019

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 291-293

رقم السجل

BIM-734019