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Human leukocyte antigen-A genotype as a predictor of cytomegalovirus-pp65 antigenemia and cytomegalovirus disease in solid-organ transplant recipients
المؤلفون المشاركون
Khalifah, Riham
Asad, Ayman
Husayn, Maha
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 17، العدد 4 (31 أكتوبر/تشرين الأول 2016)، ص ص. 345-352، 8ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2016-10-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background : Cytomegalovirus (CMV) infection is one of the most common and severe infections during the post-transplantation period.
It threatens the survival of patients and the function of the transplanted organ.
Aim of the study : To screen for CMV infection among solid organ transplantation patients using monitoring of CMV phosphoprotein 65 (CMVpp65) antigenemia and to detect if CMV infection and disease were associated with certain human leukocyte antigen (HLA)-A locus genotypes among the studied group.
Subjects and methods: Thirty solid organ transplantation patients were included for posttransplantation follow up for symptoms and signs suggestive of CMV disease upto one year.
Regular screening for CMV infection was done through CMVpp65 antigenemia detection by the immunofluorescence technique.
In addition, HLA-A genotype was determined for all patients using the line probe assay.
Results : The present study showed that 9 out of 30 patients (30%) were positive for CMVpp65 antigenemia.
The detected HLA-A alleles were HLA-A*01(no.
= 16), HLA-A*02(no.
=11), HLA-A*11(no.
= 5), HLA-A*19(no.
=1), HLA-A*24(no.
= 4), HLA-A*29(no.
= 1), HLA-A*30(no.
= 16), HLA-A*92(no.
= 4).
Among the studied cases, 40% showed HLA-A* 01–30 type.
There was a significant difference (P = 0.05) among detected HLA types as regards CMVpp65 antigenemia, with HLA-A*02_11 representing 33.3% of CMVpp65 positive patients and HLA-A*01_30 representing 57.1% of CMVpp65 negative patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khalifah, Riham& Asad, Ayman& Husayn, Maha. 2016. Human leukocyte antigen-A genotype as a predictor of cytomegalovirus-pp65 antigenemia and cytomegalovirus disease in solid-organ transplant recipients. The Egyptian Journal of Medical Human Genetics،Vol. 17, no. 4, pp.345-352.
https://search.emarefa.net/detail/BIM-737399
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khalifah, Riham…[et al.]. Human leukocyte antigen-A genotype as a predictor of cytomegalovirus-pp65 antigenemia and cytomegalovirus disease in solid-organ transplant recipients. The Egyptian Journal of Medical Human Genetics Vol. 17, no. 4 (Oct. 2016), pp.345-352.
https://search.emarefa.net/detail/BIM-737399
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khalifah, Riham& Asad, Ayman& Husayn, Maha. Human leukocyte antigen-A genotype as a predictor of cytomegalovirus-pp65 antigenemia and cytomegalovirus disease in solid-organ transplant recipients. The Egyptian Journal of Medical Human Genetics. 2016. Vol. 17, no. 4, pp.345-352.
https://search.emarefa.net/detail/BIM-737399
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 352
رقم السجل
BIM-737399
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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