Study the analgesic effect of some local medicinal plants on induced pain in laboratory mice

العناوين الأخرى

دراسة التأثير المسكن لبعض النباتات الطبية المحلية على الألم المحدث في الفئران المختبرية

مقدم أطروحة جامعية

Jasim, Nawfal Hammadi

مشرف أطروحة جامعية

Jawad, Ala al-Din H.
Jawad, Abd Allah Muhammad

الجامعة

جامعة البصرة

الكلية

كلية الطب البيطري

دولة الجامعة

العراق

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2005

الملخص الإنجليزي

Background Greater attention has been paid to traditional medicine practices in general, and herbal medicine in particular even in developing all countries. The World Health Organization also showed a clear interest in this type of medicine.

Our Islamic and Arabic heritage is rich in cumulative experiences regarding the use of herbs in medical treatment. The aim of this study is, designed, to screen some of analgesic effect of medicinal plant on the traditionally used medicinal plants for their potential analgesic effects in mice . Methods The seeds of five plants, claimed to have analgesic effect were used in this study.

These are: Nigella sativa, Apium graveolens, Trigonella foenum-graecum, Zingiber officinale and Thymus vulgaris. The oil of N.sativa seeds and the aqueous extract of the other four types of seeds were investigated.

Apple vinegar and honey which are traditionally mixed with the extracts of these seeds of these plants were also tested . Three parameters of pain: tail–flick test, hot plate test and formalin test were used to study the effect of these extracts after being administered orally to mice.

Results Three of these five extracts, showed a significant analgesic effect, these are the oil of Nigella sativa, and the aqueous extracts of Apium.

graveolens and Trigonella.

foenum graecum.

Nigella .sativa oil increased tail flick and hot-plate latency time by ٧٧% and ٦٧% when compared with pre-ingestion values respectively. Apple vinegar produced comparable effect to the N.sativa oil, while honey showed weak analgesic effect.

No additive effect when the latter two agents were combined with N.sativa oil but the effect with vinegar was higher ٦ hours after oral administration than each agent used alone. The effect of aqueous extracts of Apium.

graveolens and Trigonella.

foenum graecum were compared to Nigella .sativa oil.Zingiber.

officinale and Thymus.

valgaris aqueous extracts had a small and insignificant analgesic effect. Conclusion Out of the five plants screened for their analgesic effect, Nigella .sativa oil and the aqueous extract of Apium.

graveolens and Trigonella.

foenum graecum, in addition to apple vinegar showed a promising analgesic effect in animal models of pain. Their potential toxicity and efficacy in animals and human should be evaluated in the future.

التخصصات الرئيسية

العلوم الطبية والصيدلة والعلوم الصحية

عدد الصفحات

82

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-744252