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Factor V gene mutations and recurrent pregnancy loss
العناوين الأخرى
طفرة جين العامل الخامس و حالات الإجهاض المتكرر غير المبرر
المؤلفون المشاركون
al-Hamshari, Manal Usamah
Muhammad, Mahmud al-Suhaymi
المصدر
Reproductive Health and Population Sciences Journal
العدد
المجلد 2015، العدد 40 (31 يناير/كانون الثاني 2015)، ص ص. 25-42، 18ص.
الناشر
جامعة الأزهر المركز الدولي الإسلامي للدراسات و البحوث السكانية
تاريخ النشر
2015-01-31
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Background : Recurrent pregnancy loss (RPL) is one of the most frustrating and difficult areas in reproductive medicine because the etiology is often unknown and there are few evidence-based diagnostic and treatment strategies.
Recurrent miscarriage refers to the occurrence of three or more consecutive losses of clinically recognized pregnancies prior to the 20th week of gestation (ectopic, molar, and biochemical pregnancies are not included).
Inherited thrombophilias can result from gene mutations involved in coagulation.
A number of gene mutations are associated with recurrent pregnancy loss.
These include Factor V Leiden, Factor II Prothrombin, Fibrinogen, Factor XIII, fibrinolysis (PAI-1) and methylenetetrahydrofolatereductase gene mutations.
During pregnancy, the thrombogenic potential of these inherited disorders is enhanced because of the hypercoagulable state produced by normal pregnancy-associated changes in several coagulation factors.
Aim of the Study: The aim of the work is to assess the association between factor V Leiden and factor V HR2 gene haplotype and unexplained recurrent pregnancy loss.
Patients and Methods: This study was conducted on 310 patients classified into 2 groups.
The study group was 185 patients and control was 125 patients.
All patients were subjected for DNA extraction and factor VLeiden and factor V HR2 gene mutation by PCR.
The results were collected statistically analyzed and compared.
Conclusion and Recommendations: We recommend screening for fetal thrombophilia in the couples with recurrent pregnancy loss by studying the thrombophilic gene mutations in the affected women with recurrent pregnancy loss and their male partners.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Mahmud al-Suhaymi& al-Hamshari, Manal Usamah. 2015. Factor V gene mutations and recurrent pregnancy loss. Reproductive Health and Population Sciences Journal،Vol. 2015, no. 40, pp.25-42.
https://search.emarefa.net/detail/BIM-746016
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Mahmud al-Suhaymi& al-Hamshari, Manal Usamah. Factor V gene mutations and recurrent pregnancy loss. Reproductive Health and Population Sciences Journal No. 40 (Jan. 2015), pp.25-42.
https://search.emarefa.net/detail/BIM-746016
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Mahmud al-Suhaymi& al-Hamshari, Manal Usamah. Factor V gene mutations and recurrent pregnancy loss. Reproductive Health and Population Sciences Journal. 2015. Vol. 2015, no. 40, pp.25-42.
https://search.emarefa.net/detail/BIM-746016
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 38-41
رقم السجل
BIM-746016
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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