Correlation of CD44v6 and type IV collagen immunohistochemical expression in borderline and malignant surface epithelial tumors
المؤلفون المشاركون
Abd al-Ghani, Muhannad M.
al-Kurtas, Muhammad A.
Hasan, Isra T.
المصدر
al-Kindy College Medical Journal
العدد
المجلد 12، العدد 2 (31 ديسمبر/كانون الأول 2016)، ص ص. 34-42، 9ص.
الناشر
تاريخ النشر
2016-12-31
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: the difference in expression of type IV collagen in borderline tumors and ovarian carcinomas has been studied, but the association with adhesion molecules like CD44 have not gain enough interest.
Objectives: The purpose of this study is to assess the expression of CD44v6 and type IV collagen status in borderline tumors and invasive ovarian carcinomas and the correlation between them to define the role of these molecules in tumor invasion and metastasis.
Type of the study: A cross sectional study Methods: The study included a total of (101) formalin-fixed paraffin-embedded ovarian tissue blocks; of which (19) cases were borderline tumors and (82) cases were overt ovarian carcinomas.
Sections from each block were immunohistochemically stained for CD44v6 and type IV collagen.
Results: CD44v6 was significantly correlated with FIGO stage of borderline tumors (p=0.001) and ovarian carcinoma (<0.001) and with histological grade of ovarian carcinomas (p=0.004).
There was significantly higher expression of type IV collagen in borderline tumors compared to invasive carcinoma(p<0.001) this significance was also seen in correlation to age, stage and grade of the invasive carcinoma, no significant differences in other clinicopathological features were found.
There was negative correlation between CD44 v6 & type IV collagen which was statistically significance (P<0.05) in carcinoma but not in borderline tumors.
Conclusions: Our data suggest that observed inverse correlation of type IV collagen expression with CD44v6 positivity in surface epithelial tumors indicates that these molecules may cooperate in the invasion and progression of ovarian carcinomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Ghani, Muhannad M.& al-Kurtas, Muhammad A.& Hasan, Isra T.. 2016. Correlation of CD44v6 and type IV collagen immunohistochemical expression in borderline and malignant surface epithelial tumors. al-Kindy College Medical Journal،Vol. 12, no. 2, pp.34-42.
https://search.emarefa.net/detail/BIM-746042
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Ghani, Muhannad M.…[et al.]. Correlation of CD44v6 and type IV collagen immunohistochemical expression in borderline and malignant surface epithelial tumors. al-Kindy College Medical Journal Vol. 12, no. 2 (2016), pp.34-42.
https://search.emarefa.net/detail/BIM-746042
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Ghani, Muhannad M.& al-Kurtas, Muhammad A.& Hasan, Isra T.. Correlation of CD44v6 and type IV collagen immunohistochemical expression in borderline and malignant surface epithelial tumors. al-Kindy College Medical Journal. 2016. Vol. 12, no. 2, pp.34-42.
https://search.emarefa.net/detail/BIM-746042
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 41-42
رقم السجل
BIM-746042
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر