Synthesis, characterization and study biological activity of some new five heterocyclic derivatives for β-D-Fructopyranose
المؤلف
المصدر
al-Kufa University Journal for Biology
العدد
المجلد 8، العدد 3 (31 ديسمبر/كانون الأول 2016)، ص ص. 69-81، 13ص.
الناشر
جامعة الكوفة كلية العلوم قسم علوم الحياة
تاريخ النشر
2016-12-31
دولة النشر
العراق
عدد الصفحات
13
التخصصات الرئيسية
الموضوعات
الملخص EN
This research involves the synthesis of some new 1,2,3-Traizoliene and 1,2,3,4-Tetrazole derivatives.
Firstly was converted 2-aminpyridine to thiazolo[4,5-b]pyridin-2-amine (A) by reacting with ammonium thiocyanate in presence of glacial acetic acid.
Then, compound (B) was prepared from the reaction of (A)with p-acetamido benzenesulphonyl chloride in basic medium.
Hydrolysis of compound (B) in glacial acetic acid gives compound (C).Shiff bases (1-5) were prepared by reaction of (C) with aromatic aldehydes .
Compound (D) was synthesized from reaction of compound (C) with acetic anhydride in presence of Conc.
H2SO4 .
Chalcone derivatives (6-10) were prepared from reaction compound (D) with aromatic aldehyde.
Finally To achieve this work , Methyl- D- fructpyranoside (E) was synthesized by treating D-Fructose with Methanol in acidic medium under thermodynamically controlled conditions to make sure that the fructopyranoside are the predominant product.
The hydroxyl group on C1 was converted into mesylester derivatives (F) by reaction (E) with one equivalent of mesylchloride at 0Co The vital compound in this synthesis compound (G) was obtained by treatment (F) with one mole of sodium azide in presence of TBAB.
Reaction (G)with Schiff bases gives1,2,3,4-Tetrazole derivatives ( 11-15 ),while reaction with unsaturated compound formed 1,2,3-Traizoliene derivatives (16-20) .
The synthesized compounds have been measured by their melting points, and characterized by C.H.N.
analysis, FT-IR and 1H-MNR spectroscopy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zimam, Izzat H.. 2016. Synthesis, characterization and study biological activity of some new five heterocyclic derivatives for β-D-Fructopyranose. al-Kufa University Journal for Biology،Vol. 8, no. 3, pp.69-81.
https://search.emarefa.net/detail/BIM-747293
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zimam, Izzat H.. Synthesis, characterization and study biological activity of some new five heterocyclic derivatives for β-D-Fructopyranose. al-Kufa University Journal for Biology Vol. 8, no. 3 (2016), pp.69-81.
https://search.emarefa.net/detail/BIM-747293
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zimam, Izzat H.. Synthesis, characterization and study biological activity of some new five heterocyclic derivatives for β-D-Fructopyranose. al-Kufa University Journal for Biology. 2016. Vol. 8, no. 3, pp.69-81.
https://search.emarefa.net/detail/BIM-747293
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 80-81
رقم السجل
BIM-747293
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر