Increased concentrations of interleukin-33 in the serum and cerebrospinal fluid of patients with multiple sclerosis
المؤلفون المشاركون
Jafarzadah, Abd Allah
Mahdavi, Roya
Jamali, Mitra
Hajghani, Husayn
Nemati, Maryam
Ibrahimi, Husayn Ali
المصدر
العدد
المجلد 31، العدد 1 (31 يناير/كانون الثاني 2016)، ص ص. 40-45، 6ص.
الناشر
المجلس العماني للاختصاصات الطبية
تاريخ النشر
2016-01-31
دولة النشر
سلطنة عمان
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives: Interleukin (IL)-33 is a cytokine with both pro- and anti-inflammatory effects involved in the pathogenesis of some inflammatory diseases.
The purpose of this investigation was to evaluate the serum and cerebrospinal fluid (CSF) IL-33 concentrations in patients with multiple sclerosis (MS).
Methods: Blood specimens were obtained from 140 patients with MS (46 males and 94 females) with various disease patterns and treatment plans and 140 healthy subjects (47 males and 93 females), who acted as a control group.
CSF samples were collected from 20 MS group and 20 sex- and agematched patients with other neurological diseases of nonautoimmune etiology.
The serum and CSF concentrations of IL-33 were measured by the enzyme-linked immunosorbent assay.
Results: The serum and CSF IL-33 levels were significantly higher in the MS group compared to the control group (p<0.001 and p<0.050, respectively).
The serum IL-33 concentrations were also significantly higher in newly diagnosed (untreated) patients and patients treated with methylprednisolone or with interferon-β and methylprednisolone compared to the healthy patient group (p<0.007, p<0.002, and p<0.010, respectively).
Moreover, the serum IL-33 concentrations in patients with relapsing-remitting (RRMS), primary progressive (PPMS), and secondary progressive (SPMS) forms of the disease were significantly higher than in the healthy control group (p<0.006, p<0.001, and p<0.020, respectively).
Conclusions: Our results showed increased concentrations of IL-33 in patients with MS including both untreated and treated MS patients and patients with the RRMS, SPMS, and PPMS forms.
This suggests that IL-33 may be involved in the pathogenesis of all MS forms and treatment with methylprednisolone or both interferon-β plus methylprednisolone has no influence on IL-33 concentrations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jafarzadah, Abd Allah& Mahdavi, Roya& Jamali, Mitra& Hajghani, Husayn& Nemati, Maryam& Ibrahimi, Husayn Ali. 2016. Increased concentrations of interleukin-33 in the serum and cerebrospinal fluid of patients with multiple sclerosis. Oman Medical Journal،Vol. 31, no. 1, pp.40-45.
https://search.emarefa.net/detail/BIM-748750
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jafarzadah, Abd Allah…[et al.]. Increased concentrations of interleukin-33 in the serum and cerebrospinal fluid of patients with multiple sclerosis. Oman Medical Journal Vol. 31, no. 1 (Jan. 2016), pp.40-45.
https://search.emarefa.net/detail/BIM-748750
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jafarzadah, Abd Allah& Mahdavi, Roya& Jamali, Mitra& Hajghani, Husayn& Nemati, Maryam& Ibrahimi, Husayn Ali. Increased concentrations of interleukin-33 in the serum and cerebrospinal fluid of patients with multiple sclerosis. Oman Medical Journal. 2016. Vol. 31, no. 1, pp.40-45.
https://search.emarefa.net/detail/BIM-748750
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 45
رقم السجل
BIM-748750
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر