التقدير الطيفي ألاّني للتلميسارتان و هيدروكلوروثايزايد في أشكالهما النقية و مستحضراتهما الصيدلانية بطريقة الأطوال الموجية المزدوجة

الملخص EN

A simple, sensitive, accurate and fast spectrophotometric method for determination of Telmisartan(TEL) and Hydrochlorothiazide(HCTZ) was developed, The method based on the calculation the difference in absorbance at dual wavelengths.

The linearity of the method was between 10-45 μg\ml for two the drugs.

The optained recovery percentage Rec% 95.9295-103.8324% and 96.8254- 102.3810%, relative standard deviation RSD%, was 0.1399- 0.4318% and 0.0866-0.7213%, LOD was 0.0875 μg\ml and 0.1265 μg\ml, LOQ was 0.2916 μg\ml 0.4217 μg\ml and molar absorptivity was 10691.2 L\mol.cm and 9996 L\mol.cm for (TEL) and (HCTZ) respectively.

The method wasapplied to determination of (TEL) and (HCTZ) in pure andPharmaceutical.

Keywords: Telmisartan (TEL), Hydrochlorothiazide (HCTZ), Dual wavelengths.