Immunohitochemical expression of p53 in human colocrectal carcinoma
المؤلفون المشاركون
Shakir, Hind H.
al-Tai, Tharwa H. Hasan
Mirza, Suzan Abd al-Wahhab
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 58، العدد 3 (30 سبتمبر/أيلول 2016)، ص ص. 289-292، 4ص.
الناشر
تاريخ النشر
2016-09-30
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background:- Colorectal carcinoma is the most common cancer after the breast cancer in female and bronchus cancer in male.
P53 is a tumor suppressor gene, approximately half of colorectal cancers present mutation in p53 gene.
Objectives:- To determine the frequency and the pattern of p53expression in colorectal carcinoma by immunohistochemical technique and to correlate this expression with different clinicopathological parameters.
Materials and methods:-Thirty cases of colorectal carcinoma were included in this study, these cases were diagnosed in private pathology laboratories in Baghdad / Iraq from January 2015 to Jaune 2015.
Clinicopathological parameters such as age , gender , pathological diagnosis , including the tumor site , lymph nodes status , grade and stage of tumor were taken from patients files.Sections of 4μm stained by hematoxylen and eosin stain and immunohistochemical stained for p53.
Results: Nineteen (63.3%) of the cases were males, 11(36.7%) cases were females, with age distribution ranging from (39-89) years with a mean age of 56.5 years .
Ten cases(33.3%) located in the cecum , 3(10%)cases from each right colon , sigmoid 8 (26.7%) cases were from left colon and 6(20%) cases were from the rectum.
Histologically the tumor grade range from moderately differentiated in 27 (90%) cases, and poorly differentiated in 3 (10%) cases.
Regarding pathological staging (TNM system),2 (6.7%) cases were T2 ,24 (80%) were T3 , 4(13.3%) cases were T4.
Lymph node involvement found in 14(46.7%) cases, and distant metastasis was found in 3(10%) cases.
P53 expression was present in 11(36.7 %) cases, were distributed as follows:- weak in 1(3.3%) case,moderat in 3(10%) and marked in 7(23.4%) cases.
There was no correlation between p53 expression and the clinicopathological parameters age , sex , histopathological grade, location , lymph nodes status and tumor stage.
Conclusion: There was no significant statistical correlation between P53 expression by tumor and different clinicopathological parameters in this study
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mirza, Suzan Abd al-Wahhab& al-Tai, Tharwa H. Hasan& Shakir, Hind H.. 2016. Immunohitochemical expression of p53 in human colocrectal carcinoma. Journal of the Faculty of Medicine Baghdad،Vol. 58, no. 3, pp.289-292.
https://search.emarefa.net/detail/BIM-753065
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mirza, Suzan Abd al-Wahhab…[et al.]. Immunohitochemical expression of p53 in human colocrectal carcinoma. Journal of the Faculty of Medicine Baghdad Vol. 58, no. 3 (2016), pp.289-292.
https://search.emarefa.net/detail/BIM-753065
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mirza, Suzan Abd al-Wahhab& al-Tai, Tharwa H. Hasan& Shakir, Hind H.. Immunohitochemical expression of p53 in human colocrectal carcinoma. Journal of the Faculty of Medicine Baghdad. 2016. Vol. 58, no. 3, pp.289-292.
https://search.emarefa.net/detail/BIM-753065
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 292
رقم السجل
BIM-753065
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر