Spectrophotometric determination of nitrofurantoin drug in its pharmaceutical formulations using MBTH as a coupling reagent

العناوين الأخرى

التقدير الطيفي لدواء النيتروفيورانتوين في المستحضرات الصيدلانية باستخدام MBTH ككاشف ازدواج

المؤلفون المشاركون

Abd al-Wahid, Marwah Muayyad
Abd Allah, Hind Hadi

المصدر

Iraqi Journal of Pharmaceutical Sciences

العدد

المجلد 25، العدد 2 (31 ديسمبر/كانون الأول 2016)، ص ص. 7-14، 8ص.

الناشر

جامعة بغداد كلية الصيدلة

تاريخ النشر

2016-12-31

دولة النشر

العراق

عدد الصفحات

8

التخصصات الرئيسية

علم الصيدلة

الملخص EN

A direct, sensitive and efficient spectrophotometric method for the determination of nitrofurantoin drug (NIT) in pure as well as in dosage form (capsules) was described.

The suggested method was based on reduction NIT drug using Zn/HCl and then coupling with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in the presence of ammonium ceric sulfate.

Spectrophotometric measurement was established by recording the absorbance of the green colored product at 610 nm.

Using the optimized reaction conditions, beer’s law was obeyed in the range of 0.5-30 μg/mL, with good correlation coefficient of 0.9998 and limits of detection and quantitation of 0.163 and 0.544 μg/mL, respectively.

The accuracy and precision of the proposed method represented by recovery and relative standard deviation were satisfactory; about 99.33% and 1.16%, respectively.

The proposed method was applied for determination of NIT in its pharmaceutical forms and the results compared successfully with those obtained by standard method (British pharmacopeia method).

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Abd Allah, Hind Hadi& Abd al-Wahid, Marwah Muayyad. 2016. Spectrophotometric determination of nitrofurantoin drug in its pharmaceutical formulations using MBTH as a coupling reagent. Iraqi Journal of Pharmaceutical Sciences،Vol. 25, no. 2, pp.7-14.
https://search.emarefa.net/detail/BIM-753131

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Abd Allah, Hind Hadi& Abd al-Wahid, Marwah Muayyad. Spectrophotometric determination of nitrofurantoin drug in its pharmaceutical formulations using MBTH as a coupling reagent. Iraqi Journal of Pharmaceutical Sciences Vol. 25, no. 2 (2016), pp.7-14.
https://search.emarefa.net/detail/BIM-753131

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Abd Allah, Hind Hadi& Abd al-Wahid, Marwah Muayyad. Spectrophotometric determination of nitrofurantoin drug in its pharmaceutical formulations using MBTH as a coupling reagent. Iraqi Journal of Pharmaceutical Sciences. 2016. Vol. 25, no. 2, pp.7-14.
https://search.emarefa.net/detail/BIM-753131

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 14

رقم السجل

BIM-753131