Pharmacological studies on the effect of some locally used medicinal plants on isolated intestine of rabbits
العناوين الأخرى
دراسات فارماكولوجية لتأثير مستخلصات بعض النباتات الطبية المحلية على الأمعاء المعزولة من الأرنب
مقدم أطروحة جامعية
مشرف أطروحة جامعية
Jawad, Ala al-Din H.
Ali, Nabil A.
الجامعة
جامعة البصرة
الكلية
كلية الطب البيطري
دولة الجامعة
العراق
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2006
الملخص الإنجليزي
Back ground Greater attention has been paid to the traditional medical practices in general and herbal medicine in particular even in developed countries.
This study aimed to screen some of the traditionally used medicinal plants for their potential contraction and relaxation effect on small intestine in rabbits.
Methods Five plants claimed in folk medicine to have a contraction or relaxation effect on small intestine.
These are: Allium porrum, Nerium oleander, Cassia senna, Ammi visnaga, and Foeniculum vulgare.
They were investigated for their contraction and relaxation effect on jejunum of rabbit by using organ bath in vitro.
In order to establish the dose-response curve for the plant extracts, six male rabbits were used for each experiment.
Further pharmacological studies were performed for elucidation of the effect of most potent plant which caused a contraction or a relaxation effect on the intestinal contraction.
Pharmacological studies for the best contraction plant were made to compare between intestinal contraction after addition of the plant extract alone as agonist and intestinal contraction after addition of both antagonist drugs and the plant extract.
While pharmacological study for the relaxation plant was compared between intestinal Abstract contraction after the addition of an agonist drug alone and that after addition of both relaxation plant as antagonist followed by the addition of agonist drugs.
Results Allium porrum, Nerium oleander, Cassia senna, showed a statistically significant contraction effect except Nerium oleander which caused a non significant effect.
Ammi visnaga, Foeniculum vulgare showed a statistically significant relaxation effect in a dose dependent manner.
The most potent plant extract that caused a contraction was Allium porrum, while the most potent one that caused a relaxation was Ammi visnaga.
Conclusion Increased of intestinal contraction by Allium porrum, Nerium oleander, and Cassia senna and reduced one by Ammi visnaga, and Foeniculum vulgare were found in the present study.
Atropine, adrenaline, and chlorpheniramine reduced the effect of Allium porrum on intestinal contraction, and produce shift to the right of the dose response curve.
Neostigmine and pilocarpine effects were inhibited by administration of Ammi visnaga.
Neostigmine and pilocarpine caused a shift to the right of the dose response curve.
This effect of neostigmine is more potent than the pilocarpine and this may be due to tissue selectivity of neostigmine on the muscarnic receptors of the jejunum.
التخصصات الرئيسية
عدد الصفحات
102
قائمة المحتويات
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Materials and methods.
Chapter Four : Results.
Chapter Five : Discussion.
Conclusions and recommendations.
References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khayyun, Uras Sad. (2006). Pharmacological studies on the effect of some locally used medicinal plants on isolated intestine of rabbits. (Master's theses Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-755804
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khayyun, Uras Sad. Pharmacological studies on the effect of some locally used medicinal plants on isolated intestine of rabbits. (Master's theses Theses and Dissertations Master). University of Baghdad. (2006).
https://search.emarefa.net/detail/BIM-755804
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khayyun, Uras Sad. (2006). Pharmacological studies on the effect of some locally used medicinal plants on isolated intestine of rabbits. (Master's theses Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-755804
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-755804
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر