Assessment of inflammatory markers and malondialdehyde in patients with polycystic ovary syndrome

الملخص EN

Background and objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder of unknown etiology characterized by anovulation and hyperandrogenemia associated with other symptoms mainly insulin resistance.

The aim of the present study is to evaluate the role of inflammation and oxidative stress in the pathogenesis of PCOS.

Methods: Sixty clinically diagnosed PCOS women according to Rotterdam criteria and thirty apparently healthy individuals have been included in this case control study.

History and clinical examination were done along with laboratory tests.

Statistical analysis was done using SPSS version 18 (Chicago, USA).

Results: There were significant increases in inflammatory markers including high sensitivity CRP (P=0.001), total WBC count (P=0.03) and Erythrocyte sedimentation rate (P=0.001) in PCOS group compared to control subjects.

Furthermore, mean serum malondialdehyde (MDA) level was significantly higher in PCOS patients (P=0.005) compared to controls.

Conclusion: There is existence of low grade inflammation as well as oxidative stress represented by malondialdehyde that may play a pivotal role in PCOS pathogenesis