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The protective effect of the methanolic extract of ferula persica in rat tongue neoplasm (Oral Squamous Cell Carcinoma) induced by-nitroquinoline-1-Oxide (4-NQO)
المؤلفون المشاركون
Aghbali, Amirala
Mustafa Zadih, Samirah
Fotoohi, Suhaylah
Abd Allah, Bita
Janani, Mehrnoush
Khiavi, Munir Murad Zadih
Abbasi, Mahran Mesgari
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 18، العدد 12 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2016-12-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background: Cancer is one of the most significant causes of death around the world, and oral squamous cell carcinoma (OSCC) represents 90% of oral malignancies.
Ferula persica has been used for treatment of different diseases in Iranian traditional medicine.
Previous studies reveal some evidence relating to the value of preventing malignancies through F.
persica.
Objectives: The aim of the present study was to evaluate the protective effect of methanolic extract of Ferula persica in rat tongue neoplasm induced by 4-Nitroquinoline-1-Oxide (4-NQO).
Materials and Methods: This experimental study was carried out in the pharmaceutical research center in Tabriz, Iran.
According to ethical considerations, the results of the pilot study (five rats in each group) and pathologic changes in 30% of cases with considering = 5%, P = 80%, and d = 5%, 15 samples for each group were determined.
In this study, the OSCC was induced by 4-NQO in 60 SD rats (in four groups).
At the same time, three groups of rats received Ferula persica methanolic extract (FPME) intraperitoneally (IP) in the doses 50, 250, and 500 mg per kilogram of body weight twice each week for 14 weeks.
Results: The obtained weight differences between groups were not significant (P = 0.18).
Pathological changes in the treated and non-treated groups were significantly different (P < 0.001).
After treatment, pathologic changes were seen in groups A, B, C, and D (the cancer control group) respectively as follows: mild dysplasia - 13.3%, 26.7%, 20%, and 0.0%; moderate dysplasia - 33.3%, 13.3%, 40%, and 0.0%; severe dysplasia - 33.3%, 40%, 26.7%, and 0.0%; carcinoma in situ - 6.7%, 13.3%, 6.7%, and 20%; and squamous cell carcinoma - 13.3%, 6.7%, 6.7%, and 80%.
Conclusions: The results showed that the FPME prevented the progress of the malignancy in the OSCC model in rats.
However, further investigations are necessary to clarify effective fractions, mode of action of the FPME, and its potential therapeutic application in different types of cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aghbali, Amirala& Mustafa Zadih, Samirah& Abbasi, Mahran Mesgari& Fotoohi, Suhaylah& Abd Allah, Bita& Janani, Mehrnoush…[et al.]. 2016. The protective effect of the methanolic extract of ferula persica in rat tongue neoplasm (Oral Squamous Cell Carcinoma) induced by-nitroquinoline-1-Oxide (4-NQO). Iranian Red Crescent Medical Journal،Vol. 18, no. 12, pp.1-7.
https://search.emarefa.net/detail/BIM-758395
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aghbali, Amirala…[et al.]. The protective effect of the methanolic extract of ferula persica in rat tongue neoplasm (Oral Squamous Cell Carcinoma) induced by-nitroquinoline-1-Oxide (4-NQO). Iranian Red Crescent Medical Journal Vol. 18, no. 12 (Dec. 2016), pp.1-7.
https://search.emarefa.net/detail/BIM-758395
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aghbali, Amirala& Mustafa Zadih, Samirah& Abbasi, Mahran Mesgari& Fotoohi, Suhaylah& Abd Allah, Bita& Janani, Mehrnoush…[et al.]. The protective effect of the methanolic extract of ferula persica in rat tongue neoplasm (Oral Squamous Cell Carcinoma) induced by-nitroquinoline-1-Oxide (4-NQO). Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 12, pp.1-7.
https://search.emarefa.net/detail/BIM-758395
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7
رقم السجل
BIM-758395
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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