Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial) : a case-control study
المؤلفون المشاركون
al-Furati, Riham M.
Abu Samrah, Nashwa K.
al-Wakil, Husam
Saqr, Sharif
Hilmi, Ayman
Khashabah, Iman
Azzam, Hanan
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 18، العدد 3 (31 يوليو/تموز 2017)، ص ص. 275-279، 5ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2017-07-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background: Elevated factor VII (FVII) level is a risk factor for thromboembolic disorders.
It was reported that the FVII R353Q polymorphism is associated with variation in plasma FVII levels, where Q allele carriers were more associated with lower levels of FVII than R allele carriers.
However, the association between coagulation FVII R353 Q polymorphisms and the risk of thrombosis is uncertain.
Aim of the study: Is to investigate the contribution of factor VII R353Q gene polymorphism to the risk of thrombotic disorders development (venous and arterial) in a group of Egyptian patients.
Subjects and methods: This study was conducted on 310 subjects: 110 acute myocardial infarction (AMI) patients, 108 deep venous thrombosis (DVT) patients and 92 healthy controls.
FVII R353Q genotypes were assessed using restriction fragment length polymorphism analysis.
Results: There were no statistically significant differences in the frequency of FVII R353Q polymorphism between each of the AMI and DVT patients and the control group (P = 0.9, 0.1).
However the Q allele showed a significantly higher frequency in the AMI group (15.4%) vs.
controls (8.7%) (OR: 1.92; 95% CI: 0.98–3.7).
Bivariate analysis demonstrated no significant association between FVII R353Q genotypes and different studied risk factors, neither in arterial nor venous thrombosis.
Conclusion: FVII R353Q polymorphism did not contribute to an increased risk of thrombosis (arterial and venous); also carrying the Q allele (of R353Q) did not confer protection against acute thrombotic events.
2016 Ain Shams University.
Production and hosting by Elsevier B.V.
This is an open access article under.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azzam, Hanan& al-Furati, Riham M.& Abu Samrah, Nashwa K.& al-Wakil, Husam& Saqr, Sharif& Hilmi, Ayman…[et al.]. 2017. Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial) : a case-control study. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 3, pp.275-279.
https://search.emarefa.net/detail/BIM-760012
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azzam, Hanan…[et al.]. Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial) : a case-control study. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 3 (Jul. 2017), pp.275-279.
https://search.emarefa.net/detail/BIM-760012
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azzam, Hanan& al-Furati, Riham M.& Abu Samrah, Nashwa K.& al-Wakil, Husam& Saqr, Sharif& Hilmi, Ayman…[et al.]. Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial) : a case-control study. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 3, pp.275-279.
https://search.emarefa.net/detail/BIM-760012
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 279
رقم السجل
BIM-760012
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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