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Germline variants in the ATM gene and breast cancer susceptibility in Moroccan women : a meta-analysis
المؤلفون المشاركون
Maruf, ٍٍShayma
Hajji, Umar
Tazzite, Amal
Jouhadi, Hassan
Benider, Abd al-Latif
Nadifi, Sellama
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 18، العدد 4 (31 أكتوبر/تشرين الأول 2017)، ص ص. 329-334، 6ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2017-10-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background: The ATM gene encoding a large protein kinase is mutated in ataxia-telangiectasia (AT), an autosomale recessive disease characterized by neurological and immunological symptoms, and cancer predisposition.
Previous studies suggest that heterozygous carriers of ATM mutations have an increased risk of breast cancer compared with non carriers, but the contribution of specific variants has been difficult to estimate.
However, two functional ATM variants, c.7271T > G and c.1066–6T > G (IVS10–6T > G), are associated with increased risk for the development of breast cancer.
Methods: To investigate the role of ATM in breast cancer susceptibility, we genotyped 163 case patients with breast cancer and 150 healthy control individuals for the c.7271T > G and c.1066–6T > G (IVS10–6T > G) ATM variants using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis.
Results: We did not detect the ATM c.7271T > G and c.1066–6T > G (IVS10–6T > G) mutations in any of 150 healthy control individuals and 163 breast cancer patients, including 59 women diagnosed with breast cancer at an early age (<40 years), 10 women with bilateral breast cancer, and 6 women with ovarian cancer.
Conclusion: These observations suggested that the more common c.1066–6T > G (IVS10–6T > G) mutation and the rare c.7271T > G variant are not a risk factor for developing breast cancer in the Moroccan population.
Larger and/or combined association studies are needed to clarify this issue.-
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maruf, ٍٍShayma& Hajji, Umar& Tazzite, Amal& Jouhadi, Hassan& Benider, Abd al-Latif& Nadifi, Sellama. 2017. Germline variants in the ATM gene and breast cancer susceptibility in Moroccan women : a meta-analysis. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 4, pp.329-334.
https://search.emarefa.net/detail/BIM-760289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maruf, ٍٍShayma…[et al.]. Germline variants in the ATM gene and breast cancer susceptibility in Moroccan women : a meta-analysis. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 4 (Oct. 2017), pp.329-334.
https://search.emarefa.net/detail/BIM-760289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maruf, ٍٍShayma& Hajji, Umar& Tazzite, Amal& Jouhadi, Hassan& Benider, Abd al-Latif& Nadifi, Sellama. Germline variants in the ATM gene and breast cancer susceptibility in Moroccan women : a meta-analysis. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 4, pp.329-334.
https://search.emarefa.net/detail/BIM-760289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 333-334
رقم السجل
BIM-760289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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