Differential expression of MOC-31, Hep Par 1, and N-cadherin in primary carcinoma and metastatic adenocarcinoma in the liver
المؤلفون المشاركون
Badri, Fatimah A.
Yasin, Itimad H.
Muhammad, Said A.
al-Attar, Madihah M.
Ahmad, Muhammad A.
المصدر
Journal of Current Medical Research and Practice
العدد
المجلد 1، العدد 3 (31 ديسمبر/كانون الأول 2016)، ص ص. 54-60، 7ص.
الناشر
تاريخ النشر
2016-12-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background Immunohistochemistry plays a crucial role in the diagnosis of hepatocellular carcinoma (HCC) and in its distinction from other primary and metastatic neoplasms.
In this study, we examined the expression of MOC‑31 (Anti-epithelial cell adhesion molecule monoclonal antibody, clone number-31), hepatocyte paraffin 1 (Hep Par 1), and N‑cadherin in primary carcinoma and metastatic adenocarcinoma (AC) in the liver.
Aim The aim of this study was to evaluate the usefulness of MOC‑31, Hep Par 1, and N‑cadherin in the differential diagnosis of primary carcinoma and metastatic AC in the liver.
Materials and methods The present study included 56 specimens from cases of primary and metastatic liver tumors, including 20 primary HCCs in the liver, five intrahepatic cholangiocarcinomas, and 31 metastatic ACs in the liver.
They were studied to evaluate MOC‑31, Hep Par 1, and N‑cadherin expression using immunohistochemistry.
Results The sensitivity of MOC‑31 for AC in the studied group was 97.2%, whereas its specificity was 90%.
The sensitivity of Hep Par 1 for HCC was 75%, whereas its specificity was 100%.
The sensitivity of N‑cadherin for primary liver carcinoma was 72%, whereas its specificity was 83.9%.
Using the combination of the three antibodies, a final diagnosis could be established in 52 of 56 (92.9%) cases of studied group.
In conclusion, a panel of these three antibodies can be helpful in the distinction between primary carcinoma and metastatic AC in the liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Muhammad A.& Badri, Fatimah A.& Yasin, Itimad H.& Muhammad, Said A.& al-Attar, Madihah M.. 2016. Differential expression of MOC-31, Hep Par 1, and N-cadherin in primary carcinoma and metastatic adenocarcinoma in the liver. Journal of Current Medical Research and Practice،Vol. 1, no. 3, pp.54-60.
https://search.emarefa.net/detail/BIM-760437
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Muhammad A.…[et al.]. Differential expression of MOC-31, Hep Par 1, and N-cadherin in primary carcinoma and metastatic adenocarcinoma in the liver. Journal of Current Medical Research and Practice Vol. 1, no. 3 (Dec. 2016), pp.54-60.
https://search.emarefa.net/detail/BIM-760437
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Muhammad A.& Badri, Fatimah A.& Yasin, Itimad H.& Muhammad, Said A.& al-Attar, Madihah M.. Differential expression of MOC-31, Hep Par 1, and N-cadherin in primary carcinoma and metastatic adenocarcinoma in the liver. Journal of Current Medical Research and Practice. 2016. Vol. 1, no. 3, pp.54-60.
https://search.emarefa.net/detail/BIM-760437
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 59-60
رقم السجل
BIM-760437
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر