The nephroprotective effects of ginkgo biloba extract (EGb761) against l-NG-nitroarginine methyl ester-induced hypertension in rats : role of oxidative stress and inflammatory markers
المؤلفون المشاركون
Abd al-Dayim, Ahmad Muhammad
Farghali, Hanan S. M.
Abd al-Zahir, Ahmad O.
المصدر
Journal of Current Medical Research and Practice
العدد
المجلد 1، العدد 3 (31 ديسمبر/كانون الأول 2016)، ص ص. 79-85، 7ص.
الناشر
تاريخ النشر
2016-12-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background Ginkgo biloba extract 761 (EGb761) was studied for its nephroprotective effects in experimentally induced hypertension.
Hypertension is increasingly a cause of end‑stage renal diseases.
Increased cytokine release and oxidative stress are mechanisms that appear to be involved in the pathogenesis of hypertensive renal damage.
EGb has antioxidant and anti‑inflammatory effects and can attenuate hypertensive renal damage.
Methods and results Male adult Wistar rats were used in this study.
Hypertension was induced in these rats by administering l‑NG‑nitroarginine methyl ester (l‑NAME) (10 mg/kg/day, intraperitoneal) for 12 weeks.
Another group of rats received l‑NAME and EGb761 (100 mg/kg/day, orally) starting from the ninth week to the end of treatment.
It was found that the blood pressure was reduced at the end of 12th week in rats treated with EGb761 compared with l‑NAME‑treated (hypertensive) rats.
EGb761‑treated rats showed lower renal tissue malondialdehyde level and renal tissue tumor necrosis factor‑α level when compared with l‑NAME‑treated rats (hypertensive).
Conclusion EGb761 has antihypertensive effect; it can protect the kidney from hypertension through the reduction of renal inflammation and oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Dayim, Ahmad Muhammad& Farghali, Hanan S. M.& Abd al-Zahir, Ahmad O.. 2016. The nephroprotective effects of ginkgo biloba extract (EGb761) against l-NG-nitroarginine methyl ester-induced hypertension in rats : role of oxidative stress and inflammatory markers. Journal of Current Medical Research and Practice،Vol. 1, no. 3, pp.79-85.
https://search.emarefa.net/detail/BIM-760461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Dayim, Ahmad Muhammad…[et al.]. The nephroprotective effects of ginkgo biloba extract (EGb761) against l-NG-nitroarginine methyl ester-induced hypertension in rats : role of oxidative stress and inflammatory markers. Journal of Current Medical Research and Practice Vol. 1, no. 3 (Dec. 2016), pp.79-85.
https://search.emarefa.net/detail/BIM-760461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Dayim, Ahmad Muhammad& Farghali, Hanan S. M.& Abd al-Zahir, Ahmad O.. The nephroprotective effects of ginkgo biloba extract (EGb761) against l-NG-nitroarginine methyl ester-induced hypertension in rats : role of oxidative stress and inflammatory markers. Journal of Current Medical Research and Practice. 2016. Vol. 1, no. 3, pp.79-85.
https://search.emarefa.net/detail/BIM-760461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 84-85
رقم السجل
BIM-760461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر