Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis
المؤلفون المشاركون
Fiddah, Samiyah H.
Abd al-Azim, Mirfat I.
Muhammad, Rabab A.
Sayyid, Marwah T.
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 44، العدد 3 (30 سبتمبر/أيلول 2017)، ص ص. 118-124، 7ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2017-09-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background Interleukin-23 (IL-23) is a proinflammatory cytokine that is thought to be central to the development of autoimmune diseases.
This study was conducted to determine whether or not serum concentration of IL-23 is elevated in patients with rheumatoid arthritis (RA) and to determine the relationship between the IL-23 level and disease activity in patients with RA.
Patients and methods Serum samples were obtained from 100 patients with RA and 50 healthy controls.
Clinical parameters of the disease were determined, including 28-Joint Disease Activity Score, Clinical Disease Activity Index, Health Assessment Questionnaires, C-reactive protein, rheumatoid factor levels, anti-cyclic citrullinated peptide antibodies, and degree of bony erosions based on radiographs.
The levels of IL-23 were determined by enzyme-linked immunosorbent assay (ELISA).
The correlations between the serum levels of IL-23 and disease activity parameters of patients with RA were determined.
Results Serum IL-23 level was significantly elevated in patients with RA, 0.00–49.30 pg/ml (19.12±13.45 pg/ml) compared with healthy controls, 0.00–1.40 pg/ml (0.90 ±0.63 pg/ml) (P=0.0001).
Serum IL-23 levels in patients with RA correlated with Clinical Disease Activity Index (r=0.952, P=0.000), Health Assessment Questionnaires (r=0.953, P=0.000), and 28-Joint Disease Activity Score (r=0.967, P=0.000).
Moreover, serum IL-23 levels in patients with RA correlated with erythrocyte sedimentation rate (r=0.950, P=0.000), C-reactive protein (r=0.954, P=0.001), and rheumatoid factor (r=0.917, P=0.000).
There was a statistically significant difference between IL-23 mean values associated with different radiograph classes in patients with RA (P=0.001).
Conclusion Levels of serum IL-23 in patients with RA were significantly higher than in healthy controls.
Moreover, elevated serum IL-23 levels were correlated with clinical and laboratory parameters of disease activity.
It should be considered as a useful marker to detect active RA.
IL-23 is involved in disease progression and bony erosions in patients with RA.
Anti-IL-23 drugs could have a potential role in the treatment of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fiddah, Samiyah H.& Abd al-Azim, Mirfat I.& Muhammad, Rabab A.& Sayyid, Marwah T.. 2017. Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation،Vol. 44, no. 3, pp.118-124.
https://search.emarefa.net/detail/BIM-760717
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fiddah, Samiyah H.…[et al.]. Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation Vol. 44, no. 3 (Jul. / Sep. 2017), pp.118-124.
https://search.emarefa.net/detail/BIM-760717
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fiddah, Samiyah H.& Abd al-Azim, Mirfat I.& Muhammad, Rabab A.& Sayyid, Marwah T.. Correlation between disease activity and serum interleukin-23 in rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation. 2017. Vol. 44, no. 3, pp.118-124.
https://search.emarefa.net/detail/BIM-760717
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 133-124
رقم السجل
BIM-760717
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر