Significance of antibodies to ribosomal P proteins in lupus nephritis patients and their relation to disease activity : clinical and laboratory study
المؤلفون المشاركون
Fiddah, Samiyah H.
Abd al-Azim, Mirfat I.
Muhammad, Rabab A.
Hasan, Hana M.
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 44، العدد 3 (30 سبتمبر/أيلول 2017)، ص ص. 130-138، 9ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2017-09-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background Lupus nephritis (LN) is a prominent feature in systemic lupus erythematosus (SLE), present in 15–30% of patients with lupus at the time of the initial diagnosis and in 30–50% during the disease progression.
Objectives The aim of this study was to determine the significance of anti-ribosomal P protein (anti-P) antibodies and LN and their relation to disease activity and other SLE manifestations.
Patients and methods Fifty active LN patients were subjected to full clinical examination (assessment of SLE disease activity using the systemic lupus erythematosus disease activity index and assessment of SLE disease severity using Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index), routine laboratory investigations, anti-dsDNA antibodies, and anti-P antibodies.
Results Comparison between the data of LN in both groups (anti-P positive/anti-dsDNA negative and anti-P negative) shows that there was a statistically significant difference in age (P=0.042), hypertension (P=0.00), and psychiatric manifestations (P=0.004).
On comparison of both groups as regards vasculitis, there was a borderline statistical significance (P=0.050).
Comparison of both groups as regards creatinine level or biopsy class V showed a statistically significant difference with a higher percentage in the anti-P positive/anti-dsDNA negative group (P=0.024 and 0.040, respectively).
Conclusion Anti-P antibody-positive patients have younger ages, lower creatinine level, lower incidence of hypertension, usually class V in renal biopsy, but more susceptible to have psychiatric manifestations compared with anti-P antibody negative patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fiddah, Samiyah H.& Abd al-Azim, Mirfat I.& Muhammad, Rabab A.& Hasan, Hana M.. 2017. Significance of antibodies to ribosomal P proteins in lupus nephritis patients and their relation to disease activity : clinical and laboratory study. Egyptian Rheumatology and Rehabilitation،Vol. 44, no. 3, pp.130-138.
https://search.emarefa.net/detail/BIM-760722
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fiddah, Samiyah H.…[et al.]. Significance of antibodies to ribosomal P proteins in lupus nephritis patients and their relation to disease activity : clinical and laboratory study. Egyptian Rheumatology and Rehabilitation Vol. 44, no. 3 (Jul. / Sep. 2017), pp.130-138.
https://search.emarefa.net/detail/BIM-760722
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fiddah, Samiyah H.& Abd al-Azim, Mirfat I.& Muhammad, Rabab A.& Hasan, Hana M.. Significance of antibodies to ribosomal P proteins in lupus nephritis patients and their relation to disease activity : clinical and laboratory study. Egyptian Rheumatology and Rehabilitation. 2017. Vol. 44, no. 3, pp.130-138.
https://search.emarefa.net/detail/BIM-760722
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 138
رقم السجل
BIM-760722
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر