Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity
المؤلفون المشاركون
Hofnya, Iman R. M.
Hasab Allah, Ashraf
Twisy, Huwayda
Mursi, Hanan
المصدر
Journal of Current Medical Research and Practice
العدد
المجلد 2، العدد 1 (30 إبريل/نيسان 2017)، ص ص. 32-34، 3ص.
الناشر
تاريخ النشر
2017-04-30
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الموضوعات
الملخص EN
Background Psoriasis is a common autoimmune skin disease characterized by intense proliferation and abnormal differentiation of keratinocytes.
Recently, some microRNAs (miRs) have been proven to show an aberrant expression in psoriasis and may play a role in the pathogenesis of the disease.
Objectives The aim of this study was to detect skin miR‑369‑3p levels in patients with psoriasis and its correlation with disease severity with measurement of one of its regulated psoriasis‑related genes, SIRT, and to find the correlation between the studied parameters.
Patients and methods Skin tissues were collected, and skin miR‑369‑3p and SIRT1 gene levels were measured.
The Psoriasis Area and Severity Index scores of patients and the correlation with skin miR‑369‑3p levels were evaluated.
Correlation between miR‑369‑3p and SIRT1 gene was also evaluated.
Results Skin miR‑369‑3p levels were higher in patients with psoriasis than those in healthy controls (P = 0.01).
Skin miR‑369‑3p had an insignificant positive linear relation with Psoriasis Area and Severity Index scores in psoriasis patients (r = 0.079, P = 0.772).
Insignificant negative correlation was found between miR‑369‑3p and SIRT1 gene levels in skin.
Conclusion The expression of miR‑369‑3p is increased in skin tissues from psoriasis patients.
Further studies are needed to clarify the role of miR‑369‑3p in the pathogenesis of psoriasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hofnya, Iman R. M.& Mursi, Hanan& Hasab Allah, Ashraf& Twisy, Huwayda. 2017. Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity. Journal of Current Medical Research and Practice،Vol. 2, no. 1, pp.32-34.
https://search.emarefa.net/detail/BIM-760834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hofnya, Iman R. M.…[et al.]. Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity. Journal of Current Medical Research and Practice Vol. 2, no. 1 (Jan. / Apr. 2017), pp.32-34.
https://search.emarefa.net/detail/BIM-760834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hofnya, Iman R. M.& Mursi, Hanan& Hasab Allah, Ashraf& Twisy, Huwayda. Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity. Journal of Current Medical Research and Practice. 2017. Vol. 2, no. 1, pp.32-34.
https://search.emarefa.net/detail/BIM-760834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 34
رقم السجل
BIM-760834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر