Alu insertion deletion of ACE gene polymorphism might not affect significantly the serum bradykinin level in hypertensive patients taking ACE inhibitors
المؤلفون المشاركون
Wisnasari, Shila
Rohman, Muhammad Saifur
Yunita, Lowry
Lukitasari, Mifetika
Nuril, Maulidiyatun
Holil, Kholifah
Purwaningroom, Dian Layla
Widodo, Untung
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 18، العدد 2 (30 إبريل/نيسان 2017)، ص ص. 188-191، 4ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2017-04-30
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Angiotensin I-converting enzyme (ACE) has two homologous catalytic domains, the N- and C-domains.
Our previous study suggested that Alu insertion (I allele) in the intron 16 of ACE resulted in premature codon termination.
The I allele has only one active site in the Ndomain while the Alu deletion (D allele) still has two active sites of ACE.
Therefore the effect of I / D polymorphism of ACE on the enzyme’s ability to catalyse bradykinin is still not widely known.
Aims: This study aimed to examine the serum bradykinin level in hypertensive patients with I / D polymorphism of ACE, who were treated with ACE inhibitor.
Subjects and methods: The serum bradykinin and I/D polymorphism have been detected in 64 hypertensive patients taking ACE inhibitor (lisinopril or captopril) for at least eight weeks with good medication adherence.
The binding affinity ofACEwith its receptor was calculated by molecular docking.
Results: The findings show that genotype II is more frequent in the population the researchers observed (53.12%) compared to ID (23.44%) andDD(23.44%) variances.Onthe other hand, the bradykinin level is not affected by genotype of the ACE genes on the population.
Bradykinin increases in patients with genotype II who are given captopril, but decreases in patients treated with lisinopril.
Nevertheless, there is no statistically significant difference.
Conclusion: This study suggests that the polymorphism might not significantly affect the serum bradykinin level in hypertensive patients taking ACE inhibitors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Widodo, Untung& Wisnasari, Shila& Rohman, Muhammad Saifur& Yunita, Lowry& Lukitasari, Mifetika& Nuril, Maulidiyatun…[et al.]. 2017. Alu insertion deletion of ACE gene polymorphism might not affect significantly the serum bradykinin level in hypertensive patients taking ACE inhibitors. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 2, pp.188-191.
https://search.emarefa.net/detail/BIM-760953
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Widodo, Untung…[et al.]. Alu insertion deletion of ACE gene polymorphism might not affect significantly the serum bradykinin level in hypertensive patients taking ACE inhibitors. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 2 (Apr. 2017), pp.188-191.
https://search.emarefa.net/detail/BIM-760953
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Widodo, Untung& Wisnasari, Shila& Rohman, Muhammad Saifur& Yunita, Lowry& Lukitasari, Mifetika& Nuril, Maulidiyatun…[et al.]. Alu insertion deletion of ACE gene polymorphism might not affect significantly the serum bradykinin level in hypertensive patients taking ACE inhibitors. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 2, pp.188-191.
https://search.emarefa.net/detail/BIM-760953
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 190-191
رقم السجل
BIM-760953
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر