Validity of serum cystatin c as an early and accurate marker of glomerular filtration rate in type 1 diabetes mellitus patients
المؤلفون المشاركون
المصدر
Arab Journal of Nuclear Sciences and Applications
العدد
المجلد 50، العدد 1 (31 يناير/كانون الثاني 2017)، ص ص. 103-112، 10ص.
الناشر
الجمعية المصرية للعلوم النووية و تطبيقاتها
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
The present study aims at exploring the clinical validity of measuring cystatin C for the early and accurate assessment of GFR (as compared to measuring serum creatinine or β2 microglobulin) in patients suffering from type 1 diabetes mellitus who are at risk of developing diabetic nephropathy as well as those who have already developed the condition.
This study included 80 subjects who were further subdivided into two groups: Control group (1) which comprised 20 healthy age and sex matched children.
Patient group (2) comprised 60 patients of both sexes properly diagnosed with type 1diabetes.
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The patients were further subdivided into 3 subgroups according albumin levels in their 24 hour urine: Group 2a: 20 patients who were considered normo-albuminuric.
Group 2b: 20 patients who were considered micro-albuminuric.
Group 2c: 20 patients who were considered macro-albuminuric.
All subjects were subjected to the estimation of serum creatinine level as well as serum β2 microglobulin and serum cystatin C levels .
They were also subjected to Isotope renogram using 99mTc diethylenetriaminepentaacetic acid (DTPA) single injection technique for accurate measurement of glomerular filtration rate (GFR).
A positive correlation was observed between each of serum creatinine, β2 microglobulin, cystatin C with albumin in 24 hr urine in all the patient subgroups and this correlation was highly significant.
However, the correlation between serum cystatin C levels in the diabetic patients and albumin in 24 hr urine was higher than that observed for either serum creatinine or serum β2 microglobulin.
Cystatin C had the highest negative correlation with GFR (as measured by 99mTc-DTPA clearance) compared to either serum creatinine or serum β 2 microglobulin in group II patients.It can be concluded that cystatin C could act as an early and accurate marker of GFR and renal function in patients with type 1 diabetes mellitus at risk of developing or who have already developed diabetic nephropathy.
Keywords : Diabetic Nephropathy, Creatinine, Cystatin C, β2 Microglobulin, 99mTc- DTPA, Glomerular Filtration Rate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fathi, H. A.& Fathi, M. A.. 2017. Validity of serum cystatin c as an early and accurate marker of glomerular filtration rate in type 1 diabetes mellitus patients. Arab Journal of Nuclear Sciences and Applications،Vol. 50, no. 1, pp.103-112.
https://search.emarefa.net/detail/BIM-761005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fathi, H. A.& Fathi, M. A.. Validity of serum cystatin c as an early and accurate marker of glomerular filtration rate in type 1 diabetes mellitus patients. Arab Journal of Nuclear Sciences and Applications Vol. 50, no. 1 (Jan. 2017), pp.103-112.
https://search.emarefa.net/detail/BIM-761005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fathi, H. A.& Fathi, M. A.. Validity of serum cystatin c as an early and accurate marker of glomerular filtration rate in type 1 diabetes mellitus patients. Arab Journal of Nuclear Sciences and Applications. 2017. Vol. 50, no. 1, pp.103-112.
https://search.emarefa.net/detail/BIM-761005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 110-112
رقم السجل
BIM-761005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر