The pattern of hepatobiliary complications among Egyptian sickle cell disease children
المؤلفون المشاركون
al-Ghamrawi, Muna K.
Said, Daliya A.
Mahmud, Marwah A.
al-Raziky, Muna S.
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 65، العدد 2 (31 يوليو/تموز 2017)، ص ص. 54-59، 6ص.
الناشر
تاريخ النشر
2017-07-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
العلوم الاجتماعية (متداخلة التخصصات)
الطب البشري
الموضوعات
الملخص EN
Hepatobiliary complications are frequent among sickle cell disease patients.
Sickle cell disease has been extensively studied.
However, data about hepatobiliary abnormalities among the pediatric age group are limited.
Objective: This study aimed at describing the pattern of hepatobiliary complications among sickle cell disease patients as detected clinically, by laboratory testing and by abdominal ultrasonography.
Methods: Seventy sickle cell disease patients, aged 2–8 years, of both SS and Sb types were enrolled in this cross-sectional study.
Thorough history taking, full clinical examination, hematological and biochemical parameters assessment and abdominal ultrasonographic studies were performed to all patients.
Result: The median age of the patients was 12.5 years (mean: 11.81 ± 5.1).
Hepatomegaly was detected ultrasonographically in 24 patients (34.3%) and was more encountered among patients with increasing age (P = 0.003), patients with HbSb type (P = 0.002) and high serum ferritin levels (P = 0.047).
Gallbladder diseases were encountered in 19 patients (27.1%), and manifested as isolated stones in (7.1%), isolated mud in (5.7%), stones with mud in 2 patients (2.9%), and surgically removed stones in (11.4%).
Cholecystectomy was done in 8 patients (11.4%).
Gallbladder disease was more frequent among patients with older age (P = 0.041), more severe sickle cell disease attacks (P = 0.035), and longer duration of blood transfusion therapy (P = 0.041).
Other hepatobiliary complications were chronic hepatitis C (12.9%), benign hyperbilirubinemia (1.4%), intrahepatic cholestasis (1.4%), hepatic sequestration(1.4%), hepatic crisis (1.4%), and liver cirrhosis (1.4%).
Conclusion: Hepatobiliary complications are frequent among sickle cell disease children especially gallbladder diseases.
Repeated clinical and ultrasound screening is needed for early detection and treatment of these complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Said, Daliya A.& al-Raziky, Muna S.& al-Ghamrawi, Muna K.& Mahmud, Marwah A.. 2017. The pattern of hepatobiliary complications among Egyptian sickle cell disease children. Egyptian Pediatric Association Gazette،Vol. 65, no. 2, pp.54-59.
https://search.emarefa.net/detail/BIM-761255
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Said, Daliya A.…[et al.]. The pattern of hepatobiliary complications among Egyptian sickle cell disease children. Egyptian Pediatric Association Gazette Vol. 65, no. 2 (Jul. 2017), pp.54-59.
https://search.emarefa.net/detail/BIM-761255
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Said, Daliya A.& al-Raziky, Muna S.& al-Ghamrawi, Muna K.& Mahmud, Marwah A.. The pattern of hepatobiliary complications among Egyptian sickle cell disease children. Egyptian Pediatric Association Gazette. 2017. Vol. 65, no. 2, pp.54-59.
https://search.emarefa.net/detail/BIM-761255
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 58-59
رقم السجل
BIM-761255
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر