Comparative investigation of thyroid autoantibodies between type 1 and type 2 diabetes mellitus patients in Baghdad City

الملخص EN

The level of thyroid autoantibodies between type 1 and type 2 diabetes mellitus patients in Baghdad City were investigated.

Fifty individuals (25 female and 25 male) with type-1 DM in the age group of 10 to 35 years and seventy (35 female and 35 male) of having type-2 DM in the age group of 33 to 60 years were investigated.

A control group of twenty-five non-diabetes was included.

Serum sample collected was used to estimate anti-TPO, TG and thyroid stimulating hormone antibodies (thyroid stimulating immunoglobulin TSI and thyrotropin binding inhibitory immunoglobulin TBII) by using enzyme-linked immunosorbent assay (ELISA) technique.

The results show that there is a significant (p< 0.05) increase in the level of thyroid peroxidase antibody (TPO-Ab) in female patients with T1DM and T2M compared with control non-diabetes group.

Furthermore, there is no significant (p< 0.05) difference in the level of TPO-Ab and Tg-Ab in male patients with T1DM and T2DM compared with non-diabetes group.

The results of this study also demonstrate that there is a significant (p< 0.05) increase in the level of thyroid stimulating immunoglobulin (TSI) in male patients with T1DM compared with control non-diabetes group.

In addition, there is no significant (p< 0.05) difference in the level of TSI in female patients with T1DM and male and female with T2DM compared with non-diabetes group.

These results also illustrate that there is significant (p< 0.05) increase in the level of thyrotropin binding inhibitory immunoglobulin (TBII) in female and male patients with T2DM compared with control non-diabetes group.

Furthermore, there is no significant (p< 0.05) difference in the level of TSI in female and male patients with T1DM compared with non-diabetes group.

From this study, it concluded that the presence of antithyroid peroxidase (TPO) antibodies is helpful in predicting the development of autoimmune thyroid disorders, especially hypothyroidism.

Subclinical hypothyroidism has a negative influence on lipid metabolism and it is an independent risk factor for myocardial infarction.