Evaluation of the antioxidant protective effect of oxytocin and silymarin against gentamicin-induced nephrotoxicity in rat
العناوين الأخرى
تقييم التأثير التأكسدي الوقائي من الأوكسيتوسن و السليمارين ضد التسمم الكلوي بالجنتاميسين في الجرذان
المؤلفون المشاركون
Safwat, Ghadah M.
Radi, Abir M.
المصدر
Beni-Suef Veterinary Medical Journal
العدد
المجلد 21، العدد 1 (30 يونيو/حزيران 2011)، ص ص. 1-7، 7ص.
الناشر
جامعة بني سويف كلية الطب البيطري
تاريخ النشر
2011-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Gentamicin is an effective aminoglycoside antibiotic against severe infections.
In spite of inducing nephrotoxicity and oxidative damage, gentamicin is used clinically due to its wide spectrum of activities against Gram negative bacterial infections.
Its nephrotoxicity occurs by selective accumulation in renal proximal convoluting tubules.
Its nephrotoxicity involves renal free radical generation and reduction in antioxidant defense mechanisms.
A potential therapeutic approach to protect or reverse gentamicin-induced oxidative stress and nephrotoxicity would have more importance for clinical consequences.
Therefore, the present study was designed to investigate the possible antioxidant protective effects of oxytocin and silymarin against gentamicin-induced renal damage in rats.
A total of 40 adult male albino rats were divided into four groups.
The first group is the control group that received normal saline (1ml/kg/i.p/day for 8 consecutive days), the second group was treated with gentamicin (80mg/kg/i.p/day for 8 days), the third group was treated with gentamicin (80mg/kg/i.p/day for 8 days) and oxytocin (5 I.U/kg/i.p/day for 8 days) and the fourth group was treated with gentamicin (80mg/kg/i.p/day for 8 days) and salymarin in a dose of (50 mg/kg orally/day for 8 days).
Some biochemical and histopathological examinations of kidneys were performed after treatment for evaluation of the oxidative stress and renal nephrotoxicity.
Gentamicin treatment significantly increased serum urea and creatinine levels and AST activities.
Also gentamicin significantly decreased the total antioxidant capacity and catalase activity in renal tissues.
Renal tissue malondialdehyde (MDA) has a non significant increase, while renal reduced glutathione (GSH) wasn't changed.
Study of renal morphology showed degenerative changes in the form of cloudy swelling, hydropic degeneration and glomerular necrosis in gentamicin group.
Administration of oxytocin and silymarin with gentamicin ameliorated to some degree the biochemical changes and oxidative stress parameters against gentamicin-induced nephrotoxicity.
It was concluded that treatments with these antioxidants could have beneficial effects in treatment of gentamicin induced nephrotoxicity
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Safwat, Ghadah M.& Radi, Abir M.. 2011. Evaluation of the antioxidant protective effect of oxytocin and silymarin against gentamicin-induced nephrotoxicity in rat. Beni-Suef Veterinary Medical Journal،Vol. 21, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-761524
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Safwat, Ghadah M.& Radi, Abir M.. Evaluation of the antioxidant protective effect of oxytocin and silymarin against gentamicin-induced nephrotoxicity in rat. Beni-Suef Veterinary Medical Journal Vol. 21, no. 1 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-761524
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Safwat, Ghadah M.& Radi, Abir M.. Evaluation of the antioxidant protective effect of oxytocin and silymarin against gentamicin-induced nephrotoxicity in rat. Beni-Suef Veterinary Medical Journal. 2011. Vol. 21, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-761524
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6-7
رقم السجل
BIM-761524
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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